Electrochemical Biosensors for Sepsis Detection in Liver Cirrhosis: Advances and Insights.

Abstract

Liver cirrhosis, a progressive disease caused by chronic liver conditions, significantly increases the risk of sepsis due to immune dysfunction. The overlapping symptoms of cirrhosis and sepsis make early diagnosis particularly challenging, emphasizing the need for reliable biomarker diagnostic tools. Conventional methods are slow and result in delayed treatment, deteriorating liver function in cirrhotic patients over time. Electrochemical biosensors have emerged as promising solutions, offering rapid and precise detection of both host- and pathogen-related proteins. These platforms overcome many limitations of traditional diagnostic methods, providing enhanced sensitivity and specificity. Furthermore, the ability of the electrochemical platform to simultaneously detect multiple biomarkers has improved the sensor's reliability for comprehensive point-of-care diagnostics in clinical settings. Despite challenges, such as standardizing diagnostic thresholds and addressing operational barriers, electrochemical sensors have the potential to transform the detection and management of sepsis in liver cirrhosis. This perspective highlights the potential of the electrochemical platforms established over time to improve diagnostic precision and therapeutic strategies in managing liver-related bacterial sepsis.