{"title":"Hypothermia treatment for ocular ischemia: A multiphase porous thermal model of human eye","authors":"D. Gongal , J.R. Hetling , C.D. Foster","doi":"10.1016/j.jtherbio.2025.104139","DOIUrl":null,"url":null,"abstract":"<div><div>Localized therapeutic hypothermia is a cooling technique to reduce eye temperature to prevent neuron loss under ischemic conditions. The treatment is a non-invasive intervention technique that aids recovery and may reduce vision loss in ocular ischemia patients. The paper presents a thermal analysis simulation to predict the temperature change in the human eye under local hypothermia treatment using a scleral contact cooling ring device. A thermoregulating blood flow model is introduced to simulate realistic blood circulation in the eye using a three-phase porous media that includes tissue, inflowing blood, and outflowing blood. A transient analysis is performed using a three-dimensional human eye model consisting of an ocular globe and its surrounding fat and muscles. The results show that the optic nerve head and retina temperature decreases to the therapeutic temperature of below 34 °C in 10.58 min of application of the eye cooling device. Sensitivity analysis was performed on all the material and thermal properties to identify the critical variables in the thermal evaluation of the human eye.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"131 ","pages":"Article 104139"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thermal biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306456525000968","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Localized therapeutic hypothermia is a cooling technique to reduce eye temperature to prevent neuron loss under ischemic conditions. The treatment is a non-invasive intervention technique that aids recovery and may reduce vision loss in ocular ischemia patients. The paper presents a thermal analysis simulation to predict the temperature change in the human eye under local hypothermia treatment using a scleral contact cooling ring device. A thermoregulating blood flow model is introduced to simulate realistic blood circulation in the eye using a three-phase porous media that includes tissue, inflowing blood, and outflowing blood. A transient analysis is performed using a three-dimensional human eye model consisting of an ocular globe and its surrounding fat and muscles. The results show that the optic nerve head and retina temperature decreases to the therapeutic temperature of below 34 °C in 10.58 min of application of the eye cooling device. Sensitivity analysis was performed on all the material and thermal properties to identify the critical variables in the thermal evaluation of the human eye.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles