Credentials of chromone based probe as colorimetric sensor for the detection of Cu2+ ion: design of test paper kit and potential anticancer activity

IF 4.6 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-07-02 DOI:10.1016/j.saa.2025.126638

Mukul Bikash Maity , Panchanan Sahoo , Gurupada Bairy , Sourav Kumar Nandi , Chandan Kumar Ghosh , Chittaranjan Sinha

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引用次数: 0

Abstract

3-(5-Chloro-2,3-dihydrobenzo[d]thiazol-2-yl)-4H-chromen-4-one (MCF) is spectroscopically characterised (FT-IR, UV–Vis, ESI-MS, NMR) and has been used for the chromogenic selective recognition of Cu²⁺ ion in EtOH-H₂O (99:1, v/v) medium in presence of fourteen competitive ions and the limit of detection is 0.6 μM (WHO recommended the permissible limit, 20 μM). The Job's plot identifies the 1:1 M ratio of probe, MCF:Cu²⁺. The Benesi-Hildebrand equation calculates the binding constant, 4.9346 × 10⁴ M⁻¹ which signifies the sufficient stability of probe-analyte composite. A paper kit is designed and has been impregnated with probe. It is dried and has been used for the detection of Cu²⁺ in water. On dipping the probe kit in Cu²⁺ contaminated water with other cations develops yellowish brown color while no change is seen in absence of Cu²⁺. The biocompaitability and non-toxicity of the MCF was examined by MTT assay in MDA-MB-231 cell line. The experimental outcome depicted that the probe can be used as a potential therapeutic candidate towards TNBC treatment.

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基于色素的探针作为Cu2+离子检测的比色传感器：试纸包的设计和潜在的抗癌活性

3-（5-氯-2,3-二氢苯并[d]噻唑-2-基）- 4h - chromenon -4-one （MCF）进行了光谱表征（FT-IR、UV-Vis、ESI-MS、NMR），用于在14种竞争离子存在的EtOH-H2O （99:1, v/v）介质中对Cu2+离子的显色选择性识别，检测限为0.6 μM （WHO推荐的允许限为20 μM）。约伯的情节确定了探针的1:1 M比，MCF:Cu2+。Benesi-Hildebrand方程计算出结合常数为4.9346 × 104 M−1，表明探针-分析物复合物具有足够的稳定性。设计并浸渍了探针的纸包。经干燥后，已用于水中Cu2+的检测。在Cu2+污染的水中浸渍其他阳离子后，探针呈黄褐色，而在没有Cu2+的情况下没有变化。MTT法检测MCF对MDA-MB-231细胞株的生物相容性和无毒性。实验结果表明，该探针可作为TNBC治疗的潜在候选药物。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.