Impact of hemispheric specialization on reactive upper limb motor control after perturbations via a newly designed reactive pinch-holding-up activity test

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-07-04 DOI:10.1016/j.clinbiomech.2025.106607

Hsiu-Yun Hsu , Jie-Ning Yu , Yu-Ching Lin , Hui-Chen Su , Chia-Lin Koh , Li-Chieh Kuo

{"title":"Impact of hemispheric specialization on reactive upper limb motor control after perturbations via a newly designed reactive pinch-holding-up activity test","authors":"Hsiu-Yun Hsu , Jie-Ning Yu , Yu-Ching Lin , Hui-Chen Su , Chia-Lin Koh , Li-Chieh Kuo","doi":"10.1016/j.clinbiomech.2025.106607","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Reactive motor control is essential for optimizing movements, particularly in response to unexpected perturbations. Although hemispheric specialization is known to influence motor performance, its role in reactive motor control during fine motor tasks remains uncertain. This study aimed to develop a reliable reactive Pinch-Holding-Up Activity test to deliver controlled perturbations and measure reactive responses, evaluate the effects of various perturbation scenarios on grip responses, and investigate hemispheric influences on motor adaptation.</div></div><div><h3>Methods</h3><div>This cross-sectional observational study recruited 20 right-handed young adults to assess the reliability of the test and 26 participants to investigate the effects of hemispheric specialization. The reactive Pinch-Holding-Up Activity test comprised three conditions: predictive perturbation, unpredictable perturbation during holding, and unpredictable perturbation during lifting. Key parameters analyzed included reaction time, time to regain grip stability, peak grip force, force ratio, and baseline pinch force.</div></div><div><h3>Findings</h3><div>The test demonstrated good reliability, with the intraclass correlation coefficient improving from 0.571 to 0.868 after removing outliers. In the perturbation during lifting condition, both hands exhibited lower peak grip force compared to the perturbation during holding condition (<em>p</em> = 0.002 for the right hand; <em>p</em> < 0.001 for the left hand). The left hand showed greater precision in timing and force adjustments under both holding and lifting conditions (<em>p</em> < 0.05).</div></div><div><h3>Interpretation</h3><div>These findings indicate that the test is a reliable tool for assessing fine motor control and reveal hemispheric differences in reactive motor adaptation. The left hand's superior precision under unpredictable conditions suggests potential applications in rehabilitation and motor adaptation research.</div><div>Clinical Trial Registration: <span><span>NCT05574075</span><svg><path></path></svg></span></div></div>","PeriodicalId":50992,"journal":{"name":"Clinical Biomechanics","volume":"128 ","pages":"Article 106607"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Biomechanics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0268003325001809","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Reactive motor control is essential for optimizing movements, particularly in response to unexpected perturbations. Although hemispheric specialization is known to influence motor performance, its role in reactive motor control during fine motor tasks remains uncertain. This study aimed to develop a reliable reactive Pinch-Holding-Up Activity test to deliver controlled perturbations and measure reactive responses, evaluate the effects of various perturbation scenarios on grip responses, and investigate hemispheric influences on motor adaptation.

Methods

This cross-sectional observational study recruited 20 right-handed young adults to assess the reliability of the test and 26 participants to investigate the effects of hemispheric specialization. The reactive Pinch-Holding-Up Activity test comprised three conditions: predictive perturbation, unpredictable perturbation during holding, and unpredictable perturbation during lifting. Key parameters analyzed included reaction time, time to regain grip stability, peak grip force, force ratio, and baseline pinch force.

Findings

The test demonstrated good reliability, with the intraclass correlation coefficient improving from 0.571 to 0.868 after removing outliers. In the perturbation during lifting condition, both hands exhibited lower peak grip force compared to the perturbation during holding condition (p = 0.002 for the right hand; p < 0.001 for the left hand). The left hand showed greater precision in timing and force adjustments under both holding and lifting conditions (p < 0.05).

Interpretation

These findings indicate that the test is a reliable tool for assessing fine motor control and reveal hemispheric differences in reactive motor adaptation. The left hand's superior precision under unpredictable conditions suggests potential applications in rehabilitation and motor adaptation research.

Clinical Trial Registration: NCT05574075

查看原文本刊更多论文

通过新设计的反应性捏持活动测试，半球特化对摄动后反应性上肢运动控制的影响

主动运动控制对于优化运动是必不可少的，特别是在对意外扰动的响应中。虽然已知半球特化会影响运动表现，但其在精细运动任务中反应性运动控制中的作用仍不确定。本研究旨在建立一个可靠的反应性握紧活动测试，以提供可控的扰动和测量反应性反应，评估各种扰动情景对握力反应的影响，并研究半球对运动适应的影响。方法本横断面观察性研究招募了20名右撇子青年来评估测试的可靠性，并招募了26名参与者来研究半球专门化的影响。反应性捏持活动测试包括三种情况：预测性扰动、握持过程中不可预测的扰动和举举过程中不可预测的扰动。分析的关键参数包括反应时间、恢复握持稳定时间、峰值握持力、力比和基线夹紧力。结果：检验具有良好的信度，剔除异常值后，类内相关系数由0.571提高到0.868。在举举扰动条件下，双手握力峰值较握持扰动条件下低（p = 0.002）；p & lt;左手为0.001)。在握住和举起的情况下，左手在时间和力量调整方面表现出更高的精确度(p <；0.05)。这些发现表明，该测试是评估精细运动控制和揭示反应性运动适应半球差异的可靠工具。在不可预测的条件下，左手的优越精度表明了在康复和运动适应研究中的潜在应用。临床试验注册：NCT05574075

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.