Never let you go

IF 19.1 1区 生物学 Q1 CELL BIOLOGY
Angela R. Parrish
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引用次数: 0

Abstract

Abscission is the final step of cell division, typically occurring within 1–2 hours of furrow closure, although extended connections have been observed previously. In a recent report, Vasilev et al. show that in early mouse embryos, attachment between daughter cells are maintained much longer than in somatic cells, which allows cytoplasmic molecules to diffuse between them.

To determine how long the cytokinetic bridge was maintained after division, the authors injected photoactivatable GFP into one cell of a 4-cell stage developing mouse embryo and imaged the cells to 32-cell stage. Transfer occurs throughout interphase and ends once the microtubules maintaining the bridge disappear. Further analysis of early embryos identified a requirement of Aurora kinase to maintain these extensions, and the authors characterized the types of molecules that can be exchanged. Although these connections did not affect cell fate decisions, they did support the synchronous apoptosis of the linked cells by diffusion of apoptosis regulators.

永远不会让你离开
脱落是细胞分裂的最后一步,通常发生在沟槽关闭后1-2小时内,尽管之前也观察到延长的连接。在最近的一份报告中,Vasilev等人表明,在早期小鼠胚胎中,子细胞之间的附着比体细胞维持的时间长得多,这使得细胞质分子可以在它们之间扩散。为了确定分裂后细胞动力学桥能维持多久,作者将可光激活的GFP注射到一个4细胞期发育的小鼠胚胎细胞中,并将细胞成像到32细胞期。转移发生在整个间期,一旦维持桥的微管消失就结束。对早期胚胎的进一步分析发现,极光激酶需要维持这些延伸,作者描述了可以交换的分子类型。虽然这些连接不影响细胞命运的决定,但它们确实支持通过细胞凋亡调节剂的扩散连接细胞的同步凋亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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