{"title":"Never let you go","authors":"Angela R. Parrish","doi":"10.1038/s41556-025-01724-8","DOIUrl":null,"url":null,"abstract":"<p>Abscission is the final step of cell division, typically occurring within 1–2 hours of furrow closure, although extended connections have been observed previously. In a recent report, Vasilev et al. show that in early mouse embryos, attachment between daughter cells are maintained much longer than in somatic cells, which allows cytoplasmic molecules to diffuse between them.</p><p>To determine how long the cytokinetic bridge was maintained after division, the authors injected photoactivatable GFP into one cell of a 4-cell stage developing mouse embryo and imaged the cells to 32-cell stage. Transfer occurs throughout interphase and ends once the microtubules maintaining the bridge disappear. Further analysis of early embryos identified a requirement of Aurora kinase to maintain these extensions, and the authors characterized the types of molecules that can be exchanged. Although these connections did not affect cell fate decisions, they did support the synchronous apoptosis of the linked cells by diffusion of apoptosis regulators.</p>","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"111 1","pages":""},"PeriodicalIF":19.1000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41556-025-01724-8","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abscission is the final step of cell division, typically occurring within 1–2 hours of furrow closure, although extended connections have been observed previously. In a recent report, Vasilev et al. show that in early mouse embryos, attachment between daughter cells are maintained much longer than in somatic cells, which allows cytoplasmic molecules to diffuse between them.
To determine how long the cytokinetic bridge was maintained after division, the authors injected photoactivatable GFP into one cell of a 4-cell stage developing mouse embryo and imaged the cells to 32-cell stage. Transfer occurs throughout interphase and ends once the microtubules maintaining the bridge disappear. Further analysis of early embryos identified a requirement of Aurora kinase to maintain these extensions, and the authors characterized the types of molecules that can be exchanged. Although these connections did not affect cell fate decisions, they did support the synchronous apoptosis of the linked cells by diffusion of apoptosis regulators.
期刊介绍:
Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to:
-Autophagy
-Cancer biology
-Cell adhesion and migration
-Cell cycle and growth
-Cell death
-Chromatin and epigenetics
-Cytoskeletal dynamics
-Developmental biology
-DNA replication and repair
-Mechanisms of human disease
-Mechanobiology
-Membrane traffic and dynamics
-Metabolism
-Nuclear organization and dynamics
-Organelle biology
-Proteolysis and quality control
-RNA biology
-Signal transduction
-Stem cell biology