A liver-centric help circuit revives CD8+ T cells via IL-27

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-08 DOI:10.1038/s41590-025-02204-9

引用次数: 0

Abstract

Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 production and reprograms the hepatic immune environment. This liver-intrinsic pathway of T cell help is relevant for chronic hepatitis B virus infection and may apply to other conditions with persistent antigen stimulation, such as cancer.

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以肝脏为中心的帮助回路通过IL-27激活CD8+ T细胞

效应CD4 + T细胞通过CD40-CD40L相互作用激活Kupffer细胞，恢复肝脏中CD8 + T细胞的抗病毒功能。这触发了IL-27的产生并重新编程了肝脏免疫环境。这种肝脏内禀的T细胞帮助途径与慢性乙型肝炎病毒感染有关，也可能适用于其他持续抗原刺激的疾病，如癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.