{"title":"Sestrin-2 levels and insulin resistance in childhood obesity.","authors":"Pembe Soylu Ustkoyuncu, Derya Kocer","doi":"10.1177/10815589251359311","DOIUrl":null,"url":null,"abstract":"<p><p>Obesity is a worldwide health problem in children as well as adults. There is a relationship between oxidative stress, oxidant-antioxidant imbalance and excessive fat accumulation in visceral tissue. Oxidative stress was shown to be an important role in the development of many obesity-related metabolic disorders. Sestrin-2 is an antioxidant protein induced by oxidative stress, and protects cells against reactive oxygen radicals. Thirty obese children with insulin resistance, 29 obese children without insulin resistance between 10-18 years old and 30 healthy gender and age matched control group were included in the study. Children with a body mass index Z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Sestrin-2 levels and routine laboratory examinations were studied in these three groups. Body mass index, insulin, HOMA-IR, ALT, total cholesterol, LDL, triglyceride, C-reactive protein, waist circumference, systolic blood pressure, diastolic blood pressure, white blood cell count and uric acid levels were significantly higher in insulin resistance group than control. C-reactive protein, diastolic blood pressure and uric acid levels were found to be higher in both groups compared to the control group. Sestrin-2 levels were elevated in obese children with insulin resistance. Clinical trials number: NCT06779721.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251359311"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/10815589251359311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Obesity is a worldwide health problem in children as well as adults. There is a relationship between oxidative stress, oxidant-antioxidant imbalance and excessive fat accumulation in visceral tissue. Oxidative stress was shown to be an important role in the development of many obesity-related metabolic disorders. Sestrin-2 is an antioxidant protein induced by oxidative stress, and protects cells against reactive oxygen radicals. Thirty obese children with insulin resistance, 29 obese children without insulin resistance between 10-18 years old and 30 healthy gender and age matched control group were included in the study. Children with a body mass index Z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Sestrin-2 levels and routine laboratory examinations were studied in these three groups. Body mass index, insulin, HOMA-IR, ALT, total cholesterol, LDL, triglyceride, C-reactive protein, waist circumference, systolic blood pressure, diastolic blood pressure, white blood cell count and uric acid levels were significantly higher in insulin resistance group than control. C-reactive protein, diastolic blood pressure and uric acid levels were found to be higher in both groups compared to the control group. Sestrin-2 levels were elevated in obese children with insulin resistance. Clinical trials number: NCT06779721.