Higher C-reactive protein/albumin ratio is a potential marker for predicting amputation in patients with diabetic foot infection.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-07-07 DOI:10.20945/2359-4292-2024-0397

Li Zhang, Xufeng Gao, Meifang He, Wenyan Wang, Yuebin Zhao

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引用次数: 0

Abstract

Objective: Non-traumatic amputation resulting from diabetic foot infection (DFI) poses significant clinical and public health concerns. The C-reactive protein (CRP)/albumin ratio represents a combination of the infection level and nutritional status. This study investigated the relationship between the CRP/albumin ratio and amputation in patients with diabetic foot infections.

Subjects and methods: Patients with a DFI of Wagner grade. 3 diagnosed between January 2020 and September 2023 were retrospectively analyzed. The association between the CRP/albumin ratio and amputation was explored using multivariable logistic regression modeling. Stratified analyses were also performed to ensure the reliability of the findings.

Results: Of 301 enrolled patients, 226 underwent amputation and 75 did not. The amputation rate increased with a greater CRP/albumin ratio in the non-adjusted, minimally adjusted, and fully adjusted models, regardless of whether the CRP/albumin ratio was regarded as a categorical or continuous variable.

Conclusion: An increased CRP/albumin ratio was associated with a greater risk of amputation in individuals with DFI.

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较高的c反应蛋白/白蛋白比值是预测糖尿病足感染患者截肢的潜在指标。

目的：糖尿病足感染（DFI）引起的非创伤性截肢引起了重大的临床和公共卫生问题。c反应蛋白(CRP)/白蛋白比率代表了感染水平和营养状况的结合。本研究探讨了糖尿病足感染患者CRP/白蛋白比值与截肢的关系。研究对象和方法：Wagner级DFI患者。对2020年1月至2023年9月诊断的3例患者进行回顾性分析。采用多变量logistic回归模型探讨CRP/白蛋白比值与截肢之间的关系。还进行了分层分析，以确保研究结果的可靠性。结果：301例入组患者中，226例截肢，75例未截肢。无论CRP/白蛋白比值是分类变量还是连续变量，在未调整、最低调整和完全调整的模型中，截肢率随CRP/白蛋白比值的增大而增加。结论：在DFI患者中，CRP/白蛋白比值升高与截肢风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.