The Effect of Diabetes Mellitus on Mandibular Growth.

Abstract

Diabetes mellitus is a chronic condition characterized by insufficient insulin production or utilization. Affecting approximately 8.5% of adults globally, diabetes is categorized primarily into Type 1, Type 2, and gestational diabetes. Diabetes markedly impacts bone health, particularly affecting the growth and development of the mandible. Key alterations include impaired bone metabolism leading to diminished bone density and strength. Additionally, diabetes impairs bone healing processes, often exacerbated by deficiencies in vitamin D, thus increasing fracture risks. Understanding the interplay between diabetes and mandibular growth is essential for effective dental treatment planning and patient management. Importantly, the condition also alters essential growth factors and local blood supply to the mandibular region, compromising overall growth. Impaired bone healing and formation also affects orthodontic treatment in diabetic patients. Future research should prioritize longitudinal studies examining diabetes's long-term impact on mandibular development, exploring genetic predispositions and biomechanical properties. Understanding these mechanisms will facilitate more effective clinical strategies to mitigate the adverse effects of diabetes on bone health and optimize patient outcomes.