Association Between Low Circulating Omentin-1, Vitamin D, Antioxidants, and Trace Elements Imbalances in Women with Subclinical Hypothyroidism.

Abstract

Background and objective: Omentin-1, a novel adipokine with anti-inflammatory properties, may have a role in the pathophysiology of Subclinical hypothyroidism (SCHT). However, its association with antioxidants, vitamin D, and trace elements imbalances in SCHT remain underexplored. This study aimed to evaluate the association between low circulating Omentin-1 with vitamin D, antioxidants, and trace elements imbalances in women with newly diagnosed subclinical hypothyroidism.

Method: Fifty newly diagnosed subclinical hypothyroid females aged 18-50 years and 40 healthy females matched in age with cases are enrolled in the current study. Thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and Vitamin D were measured using electrochemiluminescence assay. Serum iron (Fe) is analyzed by a photometric measuring unit. Serum zinc (Zn), magnesium (Mg), and copper (Cu) were quantified using a colorimetric assay. Serum glutathione-s-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) were examined by spectrophotometer. Omentin-1 is analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA).

Result: Omentin-1 levels are markedly reduced in women with SCHT compared with healthy controls. Moreover, there is a substantial decrease in Serum Zn, Mg, SOD, GST, and vitamin D and a significant increase in Cu/Zn and Cu/Mg ratios among SCHT group. Omentin-1 had a substantial positive correlation with CAT, SOD, and Vitamin D, however a significant negative link was observed between omentin-1 and TSH.

Conclusion: The present study concluded that women with newly diagnosed subclinical hypothyroidism demonstrate significant changes in omentin-1, antioxidant enzymes, trace elements, and their ratios. Furthermore, low circulating omenin-1 in women with newly diagnosed SCHT is correlated with deficiencies in vitamin D, antioxidant enzymes, and trace elements imbalances.