Responsiveness and minimal important change of the Hindi version of the "Vancouver symptom score for dysfunctional elimination syndrome" questionnaire in children with overactive bladder.
{"title":"Responsiveness and minimal important change of the Hindi version of the \"Vancouver symptom score for dysfunctional elimination syndrome\" questionnaire in children with overactive bladder.","authors":"Leena Bharali, Viswas Chhapola, Soumya Tiwari","doi":"10.1016/j.jpurol.2025.06.020","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The Hindi translation of the \"Vancouver Symptom Score for Dysfunctional Elimination Syndrome\" (VSSDES) is the only valid and reliable BBD questionnaire available for use in the Hindi-speaking population. This study aimed to assess the responsiveness and minimum important change (MIC) of the Hindi-VSSDES in children with overactive bladder (OAB).</p><p><strong>Methods: </strong>This observational study included (between November 2022 and February 2024) toilet-trained children aged 5-16 years with OAB. The participants had to fill out the Hindi-VSSDES and a comparison tool (Thergaonkar scale [TS)) on their first visit and after 12 weeks of treatment. Additionally, they were asked to rate their perceived change in bladder bowel dysfunction by answering an anchor question (Global Rating of Change Scale [GRCS]) in Hindi at 12 weeks. Employing a construct validity approach, five a priori hypotheses concerning correlations, effect sizes, and the area under the ROC curve (AUC) were formulated to assess responsiveness. Responsiveness was deemed confirmed if ≥ 75 % of the hypotheses were fulfilled. The optimal cutoff on the ROC curve was the MIC value. An anchor-based MIC distribution graph was constructed. The methods complied with COSMIN recommendations.</p><p><strong>Results: </strong>Seventy-five children were screened and 70 (mean age 7.9 ± 2.6 years) completed the 12-week follow-up. The mean total scores of Hindi-VSSDES at baseline (13 ± 6.8), and the 12-week follow-up (6.3 ± 4.4) were significantly different (p < 0.001). We found no evidence of floor or ceiling effects. Four of the five predefined hypotheses were fulfilled, thereby validating the responsiveness. Hindi-VSSDES had a correlation of 0.76 and 0.5 with the TS and GRCS respectively. The AUC of ROC was 0.71 for the \"improved\" versus \"no change\" group using the GRCS anchor. The MIC value was 5.5 score points.</p><p><strong>Conclusion: </strong>The Hindi-VSSDES is a responsive tool and the first Hindi BBD questionnaire with a known MIC value. It can be used in clinical practice and research to evaluate the effectiveness of interventions in OAB.</p>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpurol.2025.06.020","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The Hindi translation of the "Vancouver Symptom Score for Dysfunctional Elimination Syndrome" (VSSDES) is the only valid and reliable BBD questionnaire available for use in the Hindi-speaking population. This study aimed to assess the responsiveness and minimum important change (MIC) of the Hindi-VSSDES in children with overactive bladder (OAB).
Methods: This observational study included (between November 2022 and February 2024) toilet-trained children aged 5-16 years with OAB. The participants had to fill out the Hindi-VSSDES and a comparison tool (Thergaonkar scale [TS)) on their first visit and after 12 weeks of treatment. Additionally, they were asked to rate their perceived change in bladder bowel dysfunction by answering an anchor question (Global Rating of Change Scale [GRCS]) in Hindi at 12 weeks. Employing a construct validity approach, five a priori hypotheses concerning correlations, effect sizes, and the area under the ROC curve (AUC) were formulated to assess responsiveness. Responsiveness was deemed confirmed if ≥ 75 % of the hypotheses were fulfilled. The optimal cutoff on the ROC curve was the MIC value. An anchor-based MIC distribution graph was constructed. The methods complied with COSMIN recommendations.
Results: Seventy-five children were screened and 70 (mean age 7.9 ± 2.6 years) completed the 12-week follow-up. The mean total scores of Hindi-VSSDES at baseline (13 ± 6.8), and the 12-week follow-up (6.3 ± 4.4) were significantly different (p < 0.001). We found no evidence of floor or ceiling effects. Four of the five predefined hypotheses were fulfilled, thereby validating the responsiveness. Hindi-VSSDES had a correlation of 0.76 and 0.5 with the TS and GRCS respectively. The AUC of ROC was 0.71 for the "improved" versus "no change" group using the GRCS anchor. The MIC value was 5.5 score points.
Conclusion: The Hindi-VSSDES is a responsive tool and the first Hindi BBD questionnaire with a known MIC value. It can be used in clinical practice and research to evaluate the effectiveness of interventions in OAB.
期刊介绍：
The Journal of Pediatric Urology publishes submitted research and clinical articles relating to Pediatric Urology which have been accepted after adequate peer review.
It publishes regular articles that have been submitted after invitation, that cover the curriculum of Pediatric Urology, and enable trainee surgeons to attain theoretical competence of the sub-specialty.
It publishes regular reviews of pediatric urological articles appearing in other journals.
It publishes invited review articles by recognised experts on modern or controversial aspects of the sub-specialty.
It enables any affiliated society to advertise society events or information in the journal without charge and will publish abstracts of papers to be read at society meetings.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
