The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.2147/JIR.S523194

Dong Li, Youwen Fan, Benyi He, Yajun Tang, Gang Deng, Rongping Guo, Min Deng, Di Tang

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引用次数: 0

Abstract

Background: Clinical tools for predicting prognosis are limited for patients with hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC)-based hepatectomy. This study evaluated the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with HCC who received HAIC-based hepatectomy.

Methods: This dual-center retrospective study included 390 patients who received HAIC-based conversion resection to investigate the relationship of NLR and LMR with survival outcomes, adverse events, and risk factors.

Results: A total of 390 patients with HCC who received HAIC-based conversion liver resection were included. Patients with NLR ≥ 5 exhibited a significantly shorter overall survival (OS) and recurrence-free survival (RFS) compared to those with NLR < 5 (P = 0.0181 and P = 0.0164, respectively). Patients with LMR ≥ 3 exhibited favorable OS and RFS rates compared to those with LMR < 3 (P = 0.0195 and P = 0.0225, respectively). Similar results were observed in patients who achieved an objective response. NLR ≥ 5 and LMR < 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 (P = 0.0131, P = 0.0104, P = 0.0055, and P = 0.0329, respectively).

Conclusion: NLR and LMR have an effective predictive capability in prognosis for patients with HCC who received HAIC-based conversion surgery. These findings may help surgeons and patients make decisions regarding HAIC-based conversion hepatectomy.

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中性粒细胞与淋巴细胞比值和淋巴细胞与单核细胞比值在接受haic转化肝切除术的肝癌患者中的预后价值：一项双中心回顾性队列研究。

背景：预测肝动脉输注化疗（HAIC）为基础的肝切除术的肝细胞癌（HCC）患者预后的临床工具有限。本研究评估了中性粒细胞与淋巴细胞比值（NLR）和淋巴细胞与单核细胞比值（LMR）在接受haic肝切除术的HCC患者中的预后意义。方法：本双中心回顾性研究纳入390例接受haic转化切除术的患者，探讨NLR和LMR与生存结局、不良事件和危险因素的关系。结果：390例HCC患者行haic转化肝切除术。与NLR < 5的患者相比，NLR≥5的患者总生存期（OS）和无复发生存期（RFS）显著缩短（P = 0.0181和P = 0.0164）。与LMR < 3的患者相比，LMR≥3的患者表现出良好的OS和RFS （P = 0.0195和P = 0.0225）。在达到客观反应的患者中观察到类似的结果。与NLR < 5和LMR≥3相比，NLR≥5和LMR < 3与OS和RFS降低显著相关（P = 0.0131, P = 0.0104, P = 0.0055和P = 0.0329）。结论：NLR和LMR对肝癌患者行haic转化手术的预后有有效的预测能力。这些发现可能有助于外科医生和患者对基于haic的转换肝切除术做出决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.