Drivers of antimicrobial resistance in pig production systems of Uganda.

IF 8.9 1区地球科学 Q1 ENVIRONMENTAL SCIENCES

Communications Earth & Environment Pub Date : 2025-01-01 Epub Date: 2025-07-02 DOI:10.1038/s43247-025-02506-8

Adrian Muwonge, Tadeo Kakooza, Paul C D Johnson, Lawrence Kisuule, Michael Kimaanga, Clovice Kankya, Barend Mark de Clare Bronsvoort, Tiziana Lembo

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Abstract

Increasing protein demand in low- and middle-income countries may accelerate livestock intensification, antibiotic overuse and antimicrobial resistance (AMR) risk. Here, we examined Uganda's growing pig sector, tracking 70 farmers and their pigs in semi-intensive and free-range systems for a year. We investigated AMR and AMR gene abundance of 668 Escherichia coli, Klebsiella and DNA isolated from 877 faecal samples using diffusion disc-method and qPCR, respectively. Pigs in semi-intensive systems were 2.2 times more likely to exhibit AMR and had higher ermB levels. AMR in free-range farmers was twice that of pigs but still 1.4 times less likely than in semi-intensive systems. AMR prevalence increased by 0.76% per month. Potential transmission events were more likely on semi-intensive farms (OR = 3.16, 95% CI: 2.1-4.3, P < 0.001), especially when farmers had higher tetQ levels than pigs; the reverse was true for ermB. Intensified urban pig production may elevate AMR risks, underscoring the need for targeted interventions.

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乌干达生猪生产系统中抗菌素耐药性的驱动因素。

低收入和中等收入国家不断增加的蛋白质需求可能加速牲畜集约化、抗生素过度使用和抗菌素耐药性风险。在这里，我们研究了乌干达的养猪业，跟踪了70名农民和他们在半集约化和自由放养系统中的猪一年。采用扩散圆盘法和qPCR对877份粪便标本中分离的668株大肠埃希菌、克雷伯菌和DNA进行AMR和AMR基因丰度分析。半集约化系统中的猪表现出抗菌素耐药性的可能性高出2.2倍，并且具有较高的ermB水平。自由放养农民的抗菌素耐药性是猪的两倍，但仍比半集约化系统低1.4倍。AMR患病率每月增加0.76%。潜在的传播事件在半集约化农场比猪更容易发生（OR = 3.16, 95% CI: 2.1-4.3， P tetQ水平）；人民币的情况正好相反。集约化的城市生猪生产可能会增加抗菌素耐药性风险，因此需要采取有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Communications Earth & Environment Earth and Planetary Sciences-General Earth and Planetary Sciences

CiteScore

8.60

自引率

2.50%

发文量

269

审稿时长

26 weeks

期刊介绍： Communications Earth & Environment is an open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the Earth, environmental and planetary sciences. Research papers published by the journal represent significant advances that bring new insight to a specialized area in Earth science, planetary science or environmental science. Communications Earth & Environment has a 2-year impact factor of 7.9 (2022 Journal Citation Reports®). Articles published in the journal in 2022 were downloaded 1,412,858 times. Median time from submission to the first editorial decision is 8 days.