Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S528663

Lam Van Nguyen, Trang Thi Thuy Nguyen

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引用次数: 0

Abstract

Purpose: This study aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) therapy in treating androgenetic alopecia (AGA) in Vietnamese patients.

Patients and methods: A prospective, non-controlled clinical study was conducted on 41 patients (17 men and 24 women) diagnosed with AGA. PRP was prepared using a standardized double-spin centrifugation protocol and injected subdermally at affected scalp areas. Patients underwent three PRP sessions at four-week intervals.

Results: PRP treatment significantly increased hair density from 40.76 ± 14.26 hairs/cm² at T0 to 66.00 ± 18.00 hairs/cm² at T3 (p < 0.05). The percentage of patients with a positive hair pull test decreased from 75.6% (T0) to 12.2% (T3) (p < 0.05). A moderate positive correlation was observed between platelet concentration and hair density improvement (ρ = 0.455, p < 0.001). Patient satisfaction was high, 97.6% satisfied and very satisfied, and only mild, transient adverse effects were noted.

Conclusion: PRP is an effective and well-tolerated therapy for AGA, significantly improving hair density and reducing hair shedding.

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自体富血小板血浆治疗雄激素性脱发的有效性：越南的一项双中心、非对照、随机临床研究。

目的：本研究旨在评价富血小板血浆（PRP）治疗越南雄激素性脱发（AGA）患者的有效性和安全性。患者和方法：对41例确诊为AGA的患者（17男24女）进行了一项前瞻性、非对照临床研究。PRP采用标准化的双自旋离心方案制备，并在受影响的头皮区域皮下注射。患者每隔四周接受三次PRP治疗。结果：PRP处理显著提高了毛发密度，从T0时的40.76±14.26根/cm²增加到T3时的66.00±18.00根/cm²（p < 0.05）。拔毛试验阳性患者比例由75.6% （T0）降至12.2% (T3) （p < 0.05）。血小板浓度与毛发密度改善呈中度正相关（ρ = 0.455, p < 0.001）。患者满意度较高，97.6%的患者满意和非常满意，仅出现轻微的、短暂的不良反应。结论：PRP治疗AGA有效且耐受性好，可显著改善毛发密度，减少毛发脱落。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.