Understanding Degeneration and Healing Pathways for Tissue-Engineered Treatment Strategies in Tendinopathy.

IF 1.9 4区生物学 Q1 ANATOMY & MORPHOLOGY

Cells Tissues Organs Pub Date : 2025-07-04 DOI:10.1159/000547258

Ana I Gonçalves, Lucrezia Righelli, Rui L Reis, Alicia J El Haj, Manuela E Gomes

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Abstract

Background: The multidisciplinary nature of the tendon tissue engineering field brings challenges to move from our basic understanding of tendon biology towards engineering strategies for tendon disorders. Such pathologies present a high risk of inflammation for young patients and limited tissue regeneration capability in ageing patients, leading to painful symptoms and impaired quality of life.

Summary: Among the complications observed in tendinopathy are degenerative changes in the extracellular matrix and aberrant tissue remodelling, accounting for a huge burden in musculoskeletal disorders worldwide. This underscores the need for early therapeutic interventions to address tissue degeneration effectively. Moreover, the development of novel therapies lacks insufficient tendinopathy models to search drug efficacy or to model healthy and pathological tissue growth events in physiologically relevant microenvironments.

Key messages: This review focuses on current treatments for tendinopathy, the biological signals involved in tendon healing, and overlook tissue engineering developments in the field.

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了解肌腱病变组织工程治疗策略的退化和愈合途径。

肌腱组织工程领域的多学科性质带来了挑战，从我们对肌腱生物学的基本理解转向肌腱疾病的工程策略。这些病理表现为年轻患者炎症风险高，老年患者组织再生能力有限，导致疼痛症状和生活质量受损。在肌腱病变中观察到的并发症包括细胞外基质的退行性改变和异常的组织重塑，这是世界范围内肌肉骨骼疾病的一个巨大负担。这强调了早期治疗干预的必要性，以有效地解决组织变性。此外，新疗法的发展缺乏足够的肌腱病变模型来搜索药物疗效或模拟生理相关微环境中健康和病理组织生长事件。本文综述了目前肌腱病变的治疗方法，肌腱愈合中的生物信号，并忽略了组织工程领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cells Tissues Organs 生物-发育生物学

CiteScore

4.90

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Cells Tissues Organs'' aims at bridging the gap between cell biology and developmental biology and the emerging fields of regenerative medicine (stem cell biology, tissue engineering, artificial organs, in vitro systems and transplantation biology). CTO offers a rapid and fair peer-review and exquisite reproduction quality. Special topic issues, entire issues of the journal devoted to a single research topic within the range of interests of the journal, are published at irregular intervals.