Genetic Characterisation of the upp Gene in Bifidobacterium bifidum PRL2010

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2025-07-06 DOI:10.1111/1751-7915.70189

Giulia Longhi, Silvia Petraro, Christian Milani, Chiara Tarracchini, Chiara Argentini, Laura Maria Vergna, Gabriele Andrea Lugli, Leonardo Mancabelli, Ciaran Lee, Francesca Turroni, Douwe van Sinderen, Marco Ventura

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Abstract

Bifidobacteria are key members of the human gut, especially during infancy. The ability of bifidobacteria to outcompete other members of the microbial communities encountered in this highly competitive human gut environment represents a key example of their evolutionary and ecological success. In the current report, we investigated the highly conserved bifidobacterial upp gene, which encodes the uracil phosphoribosyltransferase and which is involved in the pyrimidine salvage pathway. Phylogenetic analysis incorporating 107 bifidobacterial upp sequences, representing all currently known Bifidobacterium taxa, indicates that this gene followed an evolutionary route that apparently deviates from that of the 16S rRNA gene. In addition, the upp gene may support bifidobacterial survival in environments with limited uracil availability, potentially providing a competitive advantage under nutrient-restricted conditions.

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两歧双歧杆菌PRL2010中upp基因的遗传特征

双歧杆菌是人类肠道的关键成员，尤其是在婴儿期。在这种高度竞争的人类肠道环境中，双歧杆菌能够胜过其他微生物群落成员，这是它们进化和生态成功的一个关键例子。在本报告中，我们研究了高度保守的双歧杆菌upp基因，该基因编码尿嘧啶磷酸核糖基转移酶，并参与嘧啶回收途径。系统发育分析包括107个双歧杆菌的upp序列，代表了目前已知的双歧杆菌的所有分类群，表明该基因遵循明显偏离16S rRNA基因的进化路线。此外，upp基因可能支持双歧杆菌在尿嘧啶可用性有限的环境中存活，可能在营养受限的条件下提供竞争优势。

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来源期刊

Microbial Biotechnology Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

11.20

自引率

3.50%

发文量

162

审稿时长

1 months

期刊介绍： Microbial Biotechnology publishes papers of original research reporting significant advances in any aspect of microbial applications, including, but not limited to biotechnologies related to: Green chemistry; Primary metabolites; Food, beverages and supplements; Secondary metabolites and natural products; Pharmaceuticals; Diagnostics; Agriculture; Bioenergy; Biomining, including oil recovery and processing; Bioremediation; Biopolymers, biomaterials; Bionanotechnology; Biosurfactants and bioemulsifiers; Compatible solutes and bioprotectants; Biosensors, monitoring systems, quantitative microbial risk assessment; Technology development; Protein engineering; Functional genomics; Metabolic engineering; Metabolic design; Systems analysis, modelling; Process engineering; Biologically-based analytical methods; Microbially-based strategies in public health; Microbially-based strategies to influence global processes