{"title":"Attention-Deficit Hyperactivity Disorder and Childhood Allergy: Evidence From Mendelian Randomization","authors":"Maolin Liu, Zhongyao Zeng, Yuanzhi Song, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu, Lihua Kou","doi":"10.1111/cch.70135","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The association between attention-deficit hyperactivity disorder (ADHD) and allergic diseases in children has been reported in observational studies, yet whether the relationship reflects causality remains unclear.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>To address this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis using genetic instrumental variables associated with ADHD (<i>N</i> = 38 691) and childhood allergy (<i>N</i> = 5337) from the largest available genome-wide association studies. Inverse-variance weighted was used as the primary estimate, whereas Cochran's Q test and MR-Egger regression were used to detect heterogeneity and pleiotropy.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The main MR estimates indicated that ADHD significantly associated with the risk of allergic diseases in children (odds ratio = 1.14, 95% confidence interval: 1.02–1.27, <i>p</i> = 0.017). The mediation analysis via two-step MR showed no evidence for mediating roles of gut microbiota and metabolites in the effect of ADHD on childhood allergy.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>These findings may inform neuroimmune interaction and interventions for allergic diseases in children with ADHD.</p>\n </section>\n </div>","PeriodicalId":55262,"journal":{"name":"Child Care Health and Development","volume":"51 4","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Child Care Health and Development","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cch.70135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background
The association between attention-deficit hyperactivity disorder (ADHD) and allergic diseases in children has been reported in observational studies, yet whether the relationship reflects causality remains unclear.
Methods
To address this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis using genetic instrumental variables associated with ADHD (N = 38 691) and childhood allergy (N = 5337) from the largest available genome-wide association studies. Inverse-variance weighted was used as the primary estimate, whereas Cochran's Q test and MR-Egger regression were used to detect heterogeneity and pleiotropy.
Results
The main MR estimates indicated that ADHD significantly associated with the risk of allergic diseases in children (odds ratio = 1.14, 95% confidence interval: 1.02–1.27, p = 0.017). The mediation analysis via two-step MR showed no evidence for mediating roles of gut microbiota and metabolites in the effect of ADHD on childhood allergy.
Conclusions
These findings may inform neuroimmune interaction and interventions for allergic diseases in children with ADHD.
期刊介绍:
Child: care, health and development is an international, peer-reviewed journal which publishes papers dealing with all aspects of the health and development of children and young people. We aim to attract quantitative and qualitative research papers relevant to people from all disciplines working in child health. We welcome studies which examine the effects of social and environmental factors on health and development as well as those dealing with clinical issues, the organization of services and health policy. We particularly encourage the submission of studies related to those who are disadvantaged by physical, developmental, emotional and social problems. The journal also aims to collate important research findings and to provide a forum for discussion of global child health issues.