CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS

IF 4.1 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-05-20 DOI:10.1016/j.jebdp.2025.102167

CHENGZHI XIE , ZHIHUI JING , MINGYU XUE

{"title":"CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"CHENGZHI XIE , ZHIHUI JING , MINGYU XUE","doi":"10.1016/j.jebdp.2025.102167","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Aloe Vera might be beneficial to improve periodontal condition. This systematic review and meta-analysis aimed to investigate Aloe Vera’s clinical efficacy as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy.</div></div><div><h3>Methods</h3><div>We included relevant randomized controlled trials (RCTs) comparing the effectiveness of Aloe Vera (I) with a (placebo) control (C) on periodontal parameters (O) in in adults with periodontitis (P) (registration number: CRD42022336946). PubMed, Cochrane Library, Embase, and Web of Science were searched. Mean difference (MD) with standard deviations of clinical outcomes were extracted and pooled from three studies.</div></div><div><h3>Results</h3><div>Three studies were included in the systematic review and meta-analysis. Adjunctive Aloe Vera treatment reduced probing pocket depth (PPD), with MD = −0.47 (−0.78/−0.16) at 3 months, MD = −0.29 (−0.53/−0.06) at 6 months, and MD: −1.06 (−2.04/−0.08) at 12 months, compared to the control group. Overall differences for clinical attachment level (CAL) were found to be −0.56 (−0.85/−0.27) at 6 months and −0.98 (−1.28/−0.68) at 12 months, which indicated a statistically significant result favoring the test group over the control group. No significant differences were observed in reducing plaque index (PI), bleeding index (BI) at 6 months and CAL at 3 months in the local administration of Aloe Vera to SRP. Adjunctive Aloe Vera treatment reduced BI (MD: −0.40; −0.62/−0.18) at 12 months with respect to the control group.</div></div><div><h3>Conclusions</h3><div>In comparison to SRP alone/placebo, the supplementary use of Aloe Vera in SRP results in improved periodontal treatment outcomes.</div></div><div><h3>Limitations</h3><div>Limited by the quality and number of studies, the evidence was not reliable enough to support any clinical advice.</div></div><div><h3>Clinical significance</h3><div>The subgingival administration of Aloe Vera may be clinically efficacious for managing periodontal diseases.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 4","pages":"Article 102167"},"PeriodicalIF":4.1000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evidence-Based Dental Practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S153233822500082X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

Aloe Vera might be beneficial to improve periodontal condition. This systematic review and meta-analysis aimed to investigate Aloe Vera’s clinical efficacy as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy.

Methods

We included relevant randomized controlled trials (RCTs) comparing the effectiveness of Aloe Vera (I) with a (placebo) control (C) on periodontal parameters (O) in in adults with periodontitis (P) (registration number: CRD42022336946). PubMed, Cochrane Library, Embase, and Web of Science were searched. Mean difference (MD) with standard deviations of clinical outcomes were extracted and pooled from three studies.

Results

Three studies were included in the systematic review and meta-analysis. Adjunctive Aloe Vera treatment reduced probing pocket depth (PPD), with MD = −0.47 (−0.78/−0.16) at 3 months, MD = −0.29 (−0.53/−0.06) at 6 months, and MD: −1.06 (−2.04/−0.08) at 12 months, compared to the control group. Overall differences for clinical attachment level (CAL) were found to be −0.56 (−0.85/−0.27) at 6 months and −0.98 (−1.28/−0.68) at 12 months, which indicated a statistically significant result favoring the test group over the control group. No significant differences were observed in reducing plaque index (PI), bleeding index (BI) at 6 months and CAL at 3 months in the local administration of Aloe Vera to SRP. Adjunctive Aloe Vera treatment reduced BI (MD: −0.40; −0.62/−0.18) at 12 months with respect to the control group.

Conclusions

In comparison to SRP alone/placebo, the supplementary use of Aloe Vera in SRP results in improved periodontal treatment outcomes.

Limitations

Limited by the quality and number of studies, the evidence was not reliable enough to support any clinical advice.

Clinical significance

The subgingival administration of Aloe Vera may be clinically efficacious for managing periodontal diseases.

查看原文本刊更多论文

局部芦荟作为辅助牙周治疗的临床效果：系统回顾和荟萃分析

目的芦荟具有改善牙周状况的作用。本系统综述和荟萃分析旨在探讨芦荟作为非手术牙周治疗的刮治和牙根规划（SRP）辅助手段的临床疗效。方法纳入相关的随机对照试验（RCTs），比较芦荟(I)与安慰剂(C)对照(C)对牙周炎(P)成人牙周参数(O)的有效性（注册号：CRD42022336946）。检索了PubMed、Cochrane Library、Embase和Web of Science。从三个研究中提取并汇总临床结果的平均差异（MD）和标准差。结果系统评价和荟萃分析纳入了3项研究。辅助芦荟治疗降低了探测袋深度（PPD），与对照组相比，3个月时MD = −0.47(−0.78/−0.16)，6个月时MD = −0.29(−0.53/−0.06)，12个月时MD:−1.06（−2.04/−0.08）。临床依恋水平（CAL）的总体差异在6个月时为- 0.56(- 0.85/ - 0.27)，在12个月时为- 0.98(- 1.28/ - 0.68)，这表明试验组优于对照组有统计学意义。在降低斑块指数（PI）、6个月出血指数（BI）和3个月CAL方面，局部给药芦荟与SRP无显著差异。芦荟辅助治疗可降低BI (MD:−0.40；- 0.62/ - 0.18)， 12个月时与对照组相比。结论与单纯SRP /安慰剂相比，在SRP中补充使用芦荟可改善牙周治疗效果。局限性受研究质量和数量的限制，证据不够可靠，无法支持任何临床建议。临床意义芦荟龈下给药治疗牙周病在临床上可能是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.