Dual-functional hydrogel optical fiber for monitoring glucose and pH

IF 2.7 3区计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Optical Fiber Technology Pub Date : 2025-07-08 DOI:10.1016/j.yofte.2025.104337

Zhenglan Bian, Siwen Cai, Fenghong Chu, Anduo Hu, Shumin Peng, Jiaxiang Zhang

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引用次数: 0

Abstract

This research presents a dual-functional hydrogel optical fiber sensing probe capable of simultaneously detecting glucose and pH. The core and cladding of the hydrogel optical fiber were prepared using 2-hydroxy-2-methylpropiophenone as a photoinitiator, along with different concentrations of polyethylene glycol diacrylate (PEGDA). The core was doped with the fluorescent indicator o-phenanthroline ruthenium and glucose oxidase (GOD) for glucose detection, and with the fluorescent indicator 5(6)-carboxyfluorescein (5(6)-FMA) for pH measurement. For glucose detection, the probe demonstrated a linear response range of 0.6–2.2 mg/mL, with a correlation coefficient (R²) of 0.99616 and a response time of 12 min. The limit of detection (LOD) was 0.1 mg/mL. For pH detection, the probe exhibited a detection range of 4.5–8.0. Within the pH range of 5.5–7.5, the correlation coefficient (R²) was 0.99071, and the response time was 24 min. The LOD was 0.23 pH units. The probe exhibited excellent repeatability and reversibility. Its ion-permeable and biocompatible properties make it clinically significant for the simultaneous monitoring of glucose and pH in the blood of diabetic patients.

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用于监测葡萄糖和pH值的双功能水凝胶光纤

本研究提出了一种能够同时检测葡萄糖和ph值的双功能水凝胶光纤传感探针。以2-羟基-2-甲基丙烯酮为光引发剂，与不同浓度的聚乙二醇二丙烯酸酯（PEGDA）一起制备了水凝胶光纤芯和包层。用荧光指示剂邻菲罗啉钌和葡萄糖氧化酶（GOD）进行葡萄糖检测，用荧光指示剂5(6)-羧基荧光素（5(6)-FMA）进行pH测定。葡萄糖检测的线性响应范围为0.6 ~ 2.2 mg/mL，相关系数（R2）为0.99616，响应时间为12 min，检出限（LOD）为0.1 mg/mL。对于pH检测，探针的检测范围为4.5-8.0。在5.5 ~ 7.5 pH范围内，相关系数（R2）为0.99071，响应时间为24 min， LOD为0.23 pH单位。该探针具有良好的重复性和可逆性。其离子渗透性和生物相容性使其对糖尿病患者血液中葡萄糖和pH的同时监测具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optical Fiber Technology 工程技术-电信学

CiteScore

4.80

自引率

11.10%

发文量

327

审稿时长

63 days

期刊介绍： Innovations in optical fiber technology are revolutionizing world communications. Newly developed fiber amplifiers allow for direct transmission of high-speed signals over transcontinental distances without the need for electronic regeneration. Optical fibers find new applications in data processing. The impact of fiber materials, devices, and systems on communications in the coming decades will create an abundance of primary literature and the need for up-to-date reviews. Optical Fiber Technology: Materials, Devices, and Systems is a new cutting-edge journal designed to fill a need in this rapidly evolving field for speedy publication of regular length papers. Both theoretical and experimental papers on fiber materials, devices, and system performance evaluation and measurements are eligible, with emphasis on practical applications.