A body-brain (dis)equilibrium regulating transitions from health to pathology

IF 13.7 1区生物学 Q1 BIOLOGY

Physics of Life Reviews Pub Date : 2025-07-03 DOI:10.1016/j.plrev.2025.07.003

Antonio Criscuolo , Anna Czepiel , Michael Schwartze , Sonja A. Kotz

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引用次数: 0

Abstract

Recent empirical evidence and theoretical propositions motivate a paradigm shift in how we investigate neurocognitive functions. Rather than looking at the brain-behaviour relationship in isolation, research shows that cognition is shaped by reciprocal, dynamical interactions between the brain and the body across multiple timescales: from ultra-slow circadian rhythm to gastrointestinal and cardiorespiratory activity. This interest in body-brain-behaviour dynamics has raised new questions about if and how autonomic functioning, the coordination of intero- and exteroception, lifestyle and dietary choices, gut microbiome composition, hormonal cycles, and inflammation can impact behaviour, general health and well-being.

We carefully reviewed existing theoretical accounts and empirical evidence on the body-brain-behaviour interface and delineated new emerging avenues for multimodal, functional, ecologically valid, and personalized research that also integrates smart sensing technologies. In a synopsis, we propose the concept of a body-brain (dis)equilibrium regulating transitions from health to pathology.

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一种调节从健康到病理转变的身体-大脑（失调）平衡

最近的经验证据和理论命题激发了我们如何研究神经认知功能的范式转变。研究表明，认知不是孤立地看待大脑-行为关系，而是由大脑和身体在多个时间尺度上的相互、动态相互作用形成的：从超慢的昼夜节律到胃肠道和心肺活动。这种对身体-大脑-行为动力学的兴趣提出了新的问题，即自主功能、内外感觉的协调、生活方式和饮食选择、肠道微生物组组成、激素周期和炎症是否以及如何影响行为、一般健康和福祉。我们仔细回顾了现有的关于身体-大脑-行为界面的理论描述和经验证据，并描绘了集成智能传感技术的多模式、功能、生态有效和个性化研究的新途径。在摘要中，我们提出了身体-大脑（非）平衡调节从健康到病理转变的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physics of Life Reviews 生物-生物物理

CiteScore

20.30

自引率

14.50%

发文量

审稿时长

8 days

期刊介绍： Physics of Life Reviews, published quarterly, is an international journal dedicated to review articles on the physics of living systems, complex phenomena in biological systems, and related fields including artificial life, robotics, mathematical bio-semiotics, and artificial intelligent systems. Serving as a unifying force across disciplines, the journal explores living systems comprehensively—from molecules to populations, genetics to mind, and artificial systems modeling these phenomena. Inviting reviews from actively engaged researchers, the journal seeks broad, critical, and accessible contributions that address recent progress and sometimes controversial accounts in the field.