Generation of induced pluripotent stem cell lines (RFSCi003-A, RFSCi004-A) from monozygotic twins discordant for age-related macular degeneration

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-07-05 DOI:10.1016/j.scr.2025.103768

Naresh Rajendran , Wendy Runyon , Sam Hu , Ajeet Singh , Rinki Ratnapriya , Ritu Kumar , Karl Csaky , Srinivasa R. Sripathi

引用次数: 0

Abstract

Age-related macular degeneration (AMD) has significant genetic component, yet monozygotic twins frequently exhibit discordance in disease status, highlighting the role of non-genetic factors. To enable comparative studies of AMD pathogenesis, we generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of a monozygotic twin pair discordant for AMD. These iPSC lines offer a unique genetically matched resource to investigate molecular differences between affected and unaffected twins, as well as their responses to genetic, epigenetic, and environmental contributors to AMD development.

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年龄相关性黄斑变性的单卵双胞胎诱导多能干细胞系（RFSCi003-A, RFSCi004-A）的生成不一致

年龄相关性黄斑变性（AMD）具有显著的遗传成分，然而同卵双胞胎在疾病状态上经常表现出不一致，突出了非遗传因素的作用。为了对AMD发病机制进行比较研究，我们从一对与AMD不一致的单卵双胞胎的外周血单个核细胞（PBMCs）中获得了两种诱导多能干细胞（iPSC）系。这些iPSC系提供了一种独特的遗传匹配资源，用于研究患病和未患病双胞胎之间的分子差异，以及他们对遗传、表观遗传和环境因素对AMD发展的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.