Globus pallidus internus-deep brain stimulation for Lance Adams syndrome post-COVID-19: A case report and systematic review

IF 0.4 Q4 CLINICAL NEUROLOGY

Interdisciplinary Neurosurgery: Advanced Techniques and Case Management Pub Date : 2025-07-06 DOI:10.1016/j.inat.2025.102090

Amir Reza Bahadori , Parisa Javadnia , Mohammad Amin Fathollahi , Afshan Davari , Sajad Shafiee , Aidine Omidvar , Sara Mohammadian , Sara Ranji , Abbas Tafakhori

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引用次数: 0

Abstract

Objects: Lance Adams syndrome (LAS) is a chronic post-hypoxic myoclonus that predominantly arises following successful cardiopulmonary resuscitation; however, there are so rare instances following respiratory failure.

Method

This report discusses a 42-year-old female patient who developed myoclonus after COVID-19 and was diagnosed with LAS. She received globus pallidus internus-deep brain stimulation (Gpi-DBS). A systematic review following PRISMA guidelines was also conducted across multiple databases for post-hypoxic myoclonus patients who underwent DBS until November 30.

Result

The systematic review comprised eight studies focusing on post-hypoxic myoclonus, four explicitly diagnosed with LAS. All but one underwent Gpi-DBS. Improvement in myoclonus scores following DBS treatment was noted in all cases. In our case, not only were myoclonus symptoms significantly improved, but there was also an enhancement in the patient’s quality of life assessments.

Conclusion

DBS should be considered a safe and effective therapeutic strategy for patients diagnosed with LAS who resist conventional pharmacotherapy.

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苍白球内深部脑刺激治疗兰斯·亚当斯综合征1例报告及系统评价

目的：兰斯·亚当斯综合征（LAS）是一种慢性缺氧后肌阵挛，主要发生在心肺复苏成功后；然而，呼吸衰竭后出现这种情况非常罕见。方法报告1例42岁女性新冠肺炎（COVID-19）后发生肌阵挛并确诊为LAS的患者。接受苍白球内深部脑刺激（Gpi-DBS）。根据PRISMA指南，在多个数据库中对缺氧后肌阵挛患者进行了系统评价，这些患者在11月30日之前接受了DBS。结果本系统综述包括8项研究，重点关注缺氧后肌阵挛，其中4项明确诊断为LAS。除一人外，其余均接受了Gpi-DBS。在所有病例中，DBS治疗后肌阵挛评分均有改善。在我们的病例中，不仅肌阵挛症状显著改善，而且患者的生活质量评估也得到了提高。结论dbs是一种安全有效的治疗方案，可用于治疗对传统药物治疗产生抵抗的LAS患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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