Fibrothecoma/Fibroma of ovary-rare ovarian tumors with varied presentation and different modes of management: 14 years' experience from tertiary care hospitals.

IF 1.3
Journal of cancer research and therapeutics Pub Date : 2025-04-01 Epub Date: 2025-07-05 DOI:10.4103/jcrt.jcrt_66_25
Lajya Devi Goyal, D Madhuchandra, Manjit Kaur, Sandesh Ganjoo
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Abstract

Context: Fibrothecomas are a rare group of tumors of stromal cell origin, accounting for approximately 5%-8% of all ovarian tumors. These tumors are frequently mistaken as malignant due to solid consistency, association with ascites, and pleural effusion leading to unnecessary radical surgery. Due to the relative rarity of these tumors, we want to highlight eleven cases of fibrothecoma/fibromas encountered in our experience with different clinical presentations in various age groups requiring different treatment strategies based on the clinical, radiological, cytological, histopathological, and immunochemical characteristics.

Aims: Our primary aim is to emphasize the diverse presentation of rare tumors, such as fibrothecoma/fibromas, and their management across different age groups.

Settings and design: The present study was conducted over 14 years in the Department of Obstetrics and Gynecology and the Department of Pathology at Guru Gobind Singh Medical College and Hospital, Faridkot, as well as at All India Institute of Medical Sciences Bathinda.

Materials and methods: Among 526 patients with ovarian masses who were surgically managed over 14 years at our institute, we identified only 11 cases that were diagnosed as fibrothecomas or fibromas based on histopathology. We studied the detailed clinical presentations, diagnostic modalities, and management of all these patients, who were all normal at a mean follow-up of 2 years and 5 months.

Results: Over 14 years, we evaluated 526 patients presenting with ovarian masses diagnosed through clinical examination, imaging techniques, fine-needle aspiration cytology (FNAC), histopathology, and immunohistochemistry. Only 11 cases (2.09%) were identified as fibroma or fibrosarcoma. Age of the patients ranged from 14 to 76 years, with a mean age of 44.22 years. Of the 11 cases, nine patients presented with an abdominopelvic mass. Ultrasonography and contrast-enhanced CT scans typically revealed solid masses accompanied by ascites. FNAC was effective in eight cases, identifying spindle cells upon microscopic examination. Final diagnoses were confirmed through histopathology, which classified two cases as fibroma and nine as fibrothecoma. Immunohistochemistry results showed vimentin positivity in nine cases. All patients remained healthy during a mean follow-up period of 2 years and 5 months.

Statistical analysis used: Observational study.

Conclusions: This article highlights a rare ovarian tumor with details of its different clinical presentations, radiological details, cytological findings, and histopathological and immunochemical findings. According to the patient's age, these can be treated using minimally invasive and fertility-sparing techniques.

卵巢纤维膜瘤/纤维瘤-不同表现和不同治疗模式的罕见卵巢肿瘤:三级医院14年经验。
背景:纤维鞘瘤是一类罕见的间质细胞来源的肿瘤,约占卵巢肿瘤的5%-8%。这些肿瘤经常被误认为恶性肿瘤,因为它们具有坚实的一致性,并伴有腹水和胸腔积液,导致不必要的根治性手术。由于这些肿瘤的相对罕见性,我们想要强调在我们的经验中遇到的11例纤维鞘瘤/纤维瘤,不同年龄组的不同临床表现,需要基于临床、放射学、细胞学、组织病理学和免疫化学特征的不同治疗策略。目的:我们的主要目的是强调罕见肿瘤的不同表现,如纤维鞘瘤/纤维瘤,以及它们在不同年龄组的治疗。环境和设计:本研究在法里德果德古鲁·戈宾德·辛格医学院和医院的妇产科和病理学部以及全印度医学科学研究所进行了14年多的研究。材料和方法:在我院14年来手术治疗的526例卵巢肿块患者中,我们发现只有11例根据组织病理学诊断为纤维囊肿或纤维瘤。我们研究了所有患者的详细临床表现、诊断方式和治疗方法,这些患者在平均随访2年5个月后均正常。结果:14年来,我们评估了526例通过临床检查、影像学技术、细针穿刺细胞学(FNAC)、组织病理学和免疫组织化学诊断为卵巢肿块的患者。仅11例(2.09%)确诊为纤维瘤或纤维肉瘤。患者年龄14 ~ 76岁,平均年龄44.22岁。在11例病例中,9例患者表现为腹盆腔肿块。超声和增强CT扫描通常显示实性肿块伴腹水。FNAC在8例病例中有效,镜检发现梭形细胞。最终通过组织病理学确诊为纤维瘤2例,纤维膜瘤9例。免疫组化结果显示9例波形蛋白阳性。所有患者在平均2年零5个月的随访期间均保持健康。采用的统计分析:观察性研究。结论:这篇文章强调了一个罕见的卵巢肿瘤,详细介绍了其不同的临床表现、放射学细节、细胞学表现、组织病理学和免疫化学表现。根据患者的年龄,可以采用微创和保留生育能力的技术进行治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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