A dosimetric study to evaluate the inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) algorithms in HDR brachytherapy of cervical cancer.

IF 1.3
V Gogul Priean, Lalit Mohan Aggarwal, Ankur Mourya, Sunil Choudhary, Syed M Shajid, Abhijit Mandal, Ankita Singh
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Abstract

Purpose: To compare the effectiveness of the inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) algorithms in interstitial HDR brachytherapy for treatment of cervical cancer.

Methods and materials: A dosimetric study was conducted on 46 cervical cancer patients who underwent multi catheter interstitial cervical HDR brachytherapy using the Martinez Universal Perineal Interstitial Template (MUPIT). Dosimetric parameters, plan evaluation indices, and mean treatment time were assessed for each algorithm. All the parameters were compared using statistical analysis.

Results: With HIPO, significant improvements were observed in D90, D100, V100, and V200 (P < 0.05). Additionally, HIPO plans demonstrated lower doses to the bladder (B2cc) as compared to IPSA plans, whereas IPSA plans exhibited lower rectum (R2cc) and sigmoid (S2cc) doses, with statistical significance observed only for sigmoid doses. HIPO plans had better results in the plan evaluation indices such as CI, COIN, DHI, DNR, ODI, EI, NV100, GFB, GFR, GF, PQI1, PQI2, and PQS with statistical significance (P < 0.05) except for GFS. Moreover, HIPO plans had shorter mean treatment time compared to IPSA plans by 5.52 seconds, although this difference did not reach statistical significance. It was found that HIPO plans demonstrated superior dose-volumetric parameters for the high-risk clinical target volume (HR-CTV).

Conclusions: In conclusion, HIPO emerged as the preferred algorithm for interstitial cervical HDR brachytherapy due to improved dose distribution in HR-CTV and plan quality as well.

反向规划模拟退火(IPSA)和混合反向规划优化(HIPO)算法在HDR宫颈癌近距离放疗中的剂量学研究。
目的:比较逆规划模拟退火(IPSA)和混合逆规划优化(HIPO)算法在间质性HDR近距离放疗宫颈癌中的疗效。方法与材料:对46例采用Martinez通用会阴间质模板(MUPIT)行多导管间质宫颈HDR近距离放射治疗的宫颈癌患者进行剂量学研究。评估每种算法的剂量学参数、计划评价指标和平均治疗时间。采用统计学方法对各参数进行比较。结果:HIPO组D90、D100、V100、V200均有显著改善(P < 0.05)。此外,与IPSA计划相比,HIPO计划显示膀胱(B2cc)剂量较低,而IPSA计划显示直肠(R2cc)和乙状结肠(S2cc)剂量较低,仅乙状结肠剂量有统计学意义。HIPO方案在CI、COIN、DHI、DNR、ODI、EI、NV100、GFB、GFR、GF、PQI1、PQI2、PQS等方案评价指标中除GFS外,均优于HIPO方案,差异均有统计学意义(P < 0.05)。HIPO方案比IPSA方案平均治疗时间短5.52秒,但差异无统计学意义。研究发现,HIPO方案在高危临床靶体积(HR-CTV)方面表现出优越的剂量-容量参数。结论:HIPO因其改善了HR-CTV的剂量分布和计划质量,成为间质性宫颈HDR近距离放疗的首选算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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