Abiodun Tola Seriki, Chioma Obi, Amusa Azeez Olashile, Utibeima Udo Essiet, Desmond Wemimo Akingboye, Abraham Ajayi, Tenny Obiageli Gladys Egwuatu, Stella Smith
{"title":"Genomic Analysis of Multidrug Resistant <i>Enterobacter hormaechei</i> Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria.","authors":"Abiodun Tola Seriki, Chioma Obi, Amusa Azeez Olashile, Utibeima Udo Essiet, Desmond Wemimo Akingboye, Abraham Ajayi, Tenny Obiageli Gladys Egwuatu, Stella Smith","doi":"10.3947/ic.2025.0040","DOIUrl":null,"url":null,"abstract":"<p><p><i>Enterobacter hormaechei</i> has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomic analysis of a multidrug-resistant <i>E. hormaechei</i> AH1-NIMR isolated from a neonate presenting with sepsis in a tertiary hospital in Lagos, Nigeria. <i>E. hormaechei</i> AH1-NIMR was resistant to ten of twelve antibiotics that were tested. Whole-genome sequencing and bioinformatics analysis revealed that the isolate harboured several antimicrobial resistance determinants, including plasmids IncHI2-1 and Col(pHAD28). Enhanced surveillance and screening for <i>E. hormaechei</i> in sepsis cases are recommended.</p>","PeriodicalId":51616,"journal":{"name":"Infection and Chemotherapy","volume":"57 2","pages":"316-320"},"PeriodicalIF":2.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230383/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3947/ic.2025.0040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Enterobacter hormaechei has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomic analysis of a multidrug-resistant E. hormaechei AH1-NIMR isolated from a neonate presenting with sepsis in a tertiary hospital in Lagos, Nigeria. E. hormaechei AH1-NIMR was resistant to ten of twelve antibiotics that were tested. Whole-genome sequencing and bioinformatics analysis revealed that the isolate harboured several antimicrobial resistance determinants, including plasmids IncHI2-1 and Col(pHAD28). Enhanced surveillance and screening for E. hormaechei in sepsis cases are recommended.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
