Application Advances of Lentiviral Vectors: From Gene Therapy to Vaccine Development.

IF 2.4 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Enyue Fang, Guodan He, Yutong Chang, Qijia He, Pan Chen, Kongxin Hu
{"title":"Application Advances of Lentiviral Vectors: From Gene Therapy to Vaccine Development.","authors":"Enyue Fang, Guodan He, Yutong Chang, Qijia He, Pan Chen, Kongxin Hu","doi":"10.1007/s12033-025-01472-y","DOIUrl":null,"url":null,"abstract":"<p><p>Since their development in the 1990s, the applications of lentiviral vectors have rapidly extended to the fields of gene and cancer therapy, as well as vaccine development, owing to their unique advantages of efficiently transducing both dividing and nondividing cells and achieving stable and long-term expression of genes. However, with their clinical application, potential safety issues have emerged, such as the possibility of insertional oncogenesis, immune reactions, and tumorigenesis, which have attracted widespread attention from the academic and clinical communities. In this review, we thoroughly explore the strategies used to optimize lentiviral vectors and assess their potential benefits and risks in different fields. We summarize the latest research on the use of lentiviral vectors, covering their development, classification, and applications in cancer therapy, treatment of genetic diseases, and vaccine development, as well as discussing important safety considerations. This review acts as an informative reference for academics and clinicians, providing insights into the potential future research directions and possible clinical applications of lentiviral vectors. We hope that this review will promote the continuous improvement of lentiviral vector technology and realize its full therapeutic potential in the treatment and prevention of diseases.</p>","PeriodicalId":18865,"journal":{"name":"Molecular Biotechnology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12033-025-01472-y","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Since their development in the 1990s, the applications of lentiviral vectors have rapidly extended to the fields of gene and cancer therapy, as well as vaccine development, owing to their unique advantages of efficiently transducing both dividing and nondividing cells and achieving stable and long-term expression of genes. However, with their clinical application, potential safety issues have emerged, such as the possibility of insertional oncogenesis, immune reactions, and tumorigenesis, which have attracted widespread attention from the academic and clinical communities. In this review, we thoroughly explore the strategies used to optimize lentiviral vectors and assess their potential benefits and risks in different fields. We summarize the latest research on the use of lentiviral vectors, covering their development, classification, and applications in cancer therapy, treatment of genetic diseases, and vaccine development, as well as discussing important safety considerations. This review acts as an informative reference for academics and clinicians, providing insights into the potential future research directions and possible clinical applications of lentiviral vectors. We hope that this review will promote the continuous improvement of lentiviral vector technology and realize its full therapeutic potential in the treatment and prevention of diseases.

慢病毒载体的应用进展:从基因治疗到疫苗研制。
慢病毒载体自20世纪90年代发展以来,由于其在有效转导分裂和非分裂细胞以及实现基因稳定和长期表达方面的独特优势,其应用已迅速扩展到基因和癌症治疗以及疫苗开发领域。然而,随着其临床应用,出现了插入性肿瘤、免疫反应、肿瘤发生的可能性等安全性问题,引起了学术界和临床界的广泛关注。在这篇综述中,我们深入探讨了用于优化慢病毒载体的策略,并评估了它们在不同领域的潜在收益和风险。我们总结了慢病毒载体的最新研究,包括它们的发展、分类、在癌症治疗、遗传疾病治疗和疫苗开发中的应用,并讨论了重要的安全性问题。本文旨在为学术界和临床医生提供信息参考,为慢病毒载体未来的潜在研究方向和可能的临床应用提供见解。希望本文的综述能够促进慢病毒载体技术的不断完善,充分发挥其在疾病治疗和预防方面的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Molecular Biotechnology
Molecular Biotechnology 医学-生化与分子生物学
CiteScore
4.10
自引率
3.80%
发文量
165
审稿时长
6 months
期刊介绍: Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信