Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction.

Abstract

Myocardial markers and inflammatory factors have been identified as risk factors for the development of sepsis-induced cardiac dysfunction (SIC), the prognostic significance and clinical utility of utilizing a multi-index combined prognostic approach remain uncertain. Our objective was to establish a "risk score" utilizing clinical indexes to provide short-term prognostic insight for individuals with SIC. Utilizing Lasso regression and COX regression analysis, we identified a history of diabetes, CRP, and NT-proBNP on day 3 as independent risk factors for 28-day mortality in SIC patients. Specifically, the Cox regression analysis identified a hazard ratio of 24.74 (95% CI: 5.90-103.71) for the high-risk group. The prognostic thresholds for CRP and NT-proBNP were determined to be 83.3 mg/L and 1720.7 ng/L, respectively. In conclusion, a "risk score" predictive model incorporating diabetes history, CRP, and NT-proBNP was developed to assess 28-day mortality in patients with SIC.