Anthropometry and Body Composition in Childhood: Follow-Up of a Randomised, Double-Blinded Controlled Trial With a Modified, Low-Protein Infant Formula During Infancy.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-07-04 DOI:10.1111/ijpo.70038

Jacqueline Muts, Stefanie M P Kouwenhoven, Nadja Antl, Marieke Abrahamse-Berkeveld, Britt J van Keulen, Jos W R Twisk, Dewi van Harskamp, Chris H P van den Akker, Berthold Koletzko, Johannes B van Goudoever

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引用次数: 0

Abstract

Introduction: Formula feeding is associated with an increased obesity risk compared to breastfeeding, possibly due to its higher protein content. We aimed to investigate the influence of feeding a modified, low-protein infant formula during the first 6 months of life on growth and body composition at 6 years.

Methods: Healthy term-born infants were randomised to receive a low-protein (mLP) infant formula with modified amino acid composition (n = 90; 1.7 g protein/100 kcal) or a control infant formula (CTRL) (n = 88; 2.1 g protein/100 kcal) up to 6 months. A breastfed (BF, n = 67) group served as a reference. At 6 years, anthropometry and body composition (air-displacement plethysmography) were measured.

Results: A total of 106 infants were measured at 6y follow-up, (n = 39 mLP; n = 33 CTRL; n = 34 BF). No significant differences were observed in mean weight, length, BMI, or fat mass percentage. However, the mean fat-free mass was lower in the mLP compared to the CTRL group (-1240 g; 95% CI: -1889 to -591, p < 0.001). Moreover, both formula groups had a higher absolute fat mass when compared to the breastfed group (p = 0.01).

Conclusions: Feeding a mLP formula during early life did not have beneficial effects on body composition in a subset of infants studied at age 6 year.

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儿童时期的人体测量和身体组成：一项随机、双盲对照试验的随访，在婴儿期使用改良的低蛋白婴儿配方奶粉。

与母乳喂养相比，配方奶喂养与肥胖风险增加有关，可能是由于其更高的蛋白质含量。我们的目的是研究在出生后前6个月喂养改良的低蛋白婴儿配方奶粉对6岁时生长和身体成分的影响。方法：健康足月婴儿随机接受改良氨基酸组成的低蛋白（mLP）婴儿配方奶粉(n = 90；1.7 g蛋白质/100千卡)或对照婴儿配方奶粉（CTRL） (n = 88；2.1克蛋白质/100千卡)，可达6个月。以母乳喂养组（BF, n = 67）为参照。6岁时，测量人体测量和身体组成（空气置换体积脉搏图）。结果：随访6年时共测量106例婴儿，(n = 39 mLP；n = 33 CTRL；n = 34 BF)。在平均体重、身高、BMI或脂肪质量百分比方面没有观察到显著差异。然而，与CTRL组相比，mLP组的平均无脂质量较低(-1240 g；95% CI: -1889至-591，p结论：在6岁时的研究中，早期喂养mLP配方奶粉对婴儿的身体成分没有有益的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.