The Efficacy of Intense Pulsed Light Versus Topical Nicotinamide 4% in Treatment of Acne Vulgaris.

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2025-07-01 DOI:10.1111/phpp.70025

Hagar Atteya Al-Sharnoby, Reda Hassan Al-Bakary, Samia Othman Nassar, Reem Adel Mahmoud Mesbah

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引用次数: 0

Abstract

Background: Intense pulsed light (IPL) is a Food and Drug Administration-approved device for the management of several dermatologic disorders, including Acne vulgaris (AV). Nicotinamide, a form of vitamin B3, constitutes a possible therapeutic approach for AV. It has powerful anti-inflammatory benefits without the danger of bacterial resistance or systemic adverse effects.

Purpose: To contrast the efficacy and safety of IPL and topical nicotinamide 4% cream in the management of AV.

Methods: This comparative work was conducted on 20 participants aged from 18 to 40 years both sexes, with different clinical types of AV. The patients' faces were allocated into two sides: The right side of the face was treated with 4 IPL sessions at two-weeks intervals, while the left side was treated with topical nicotinamide 4% cream twice daily for 2 months. Clinical assessment of acne lesions in all patients was performed before starting treatment and one and 3 months after the last session.

Results: A significant enhancement of inflammatory acne lesions existed after treatment with IPL and nicotinamide 4% topical cream. A significant variation existed between the two sides of the face after treatment according to the degree of enhancement, in which the IPL showed better improvement than the nicotinamide 4% cream. Moreover, patients were more satisfied with IPL treatment.

Conclusions: IPL seems to be a safe and effective therapy in the management of mild to moderate inflammatory acne and an alternative to other systemic modalities of acne treatment when they are contraindicated.

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强脉冲光与4%烟酰胺外用治疗寻常性痤疮的疗效比较。

背景：强脉冲光（IPL）是食品和药物管理局批准的用于治疗几种皮肤病的设备，包括寻常痤疮（AV）。烟酰胺是维生素B3的一种形式，可能是AV的一种治疗方法。它具有强大的抗炎作用，而不会产生细菌耐药性或全身不良反应的危险。目的：比较IPL和4%烟酰胺乳膏治疗AV的疗效和安全性。方法：对20例18 ~ 40岁男性、不同临床类型AV的患者进行对比研究。将患者面部分为两侧：右侧面部每隔两周进行4次IPL治疗，左侧面部每天两次使用4%烟酰胺乳膏治疗，持续2个月。在开始治疗前和最后一次治疗后1个月和3个月对所有患者的痤疮病变进行临床评估。结果：IPL和烟酰胺4%外用乳膏治疗后，炎性痤疮病变明显增强。根据增强程度，治疗后两侧面部之间存在显著差异，其中IPL的改善效果优于烟酰胺4%乳膏。此外，患者对IPL治疗更满意。结论：IPL似乎是一种安全有效的治疗轻中度炎症性痤疮的方法，当有禁忌时，可以替代其他系统性痤疮治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.