Recent advances in terahertz biochemical sensing technology: principles, evolution and applications

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-07-03 DOI:10.1016/j.trac.2025.118362

Chen Wang , Xiaonan Li , Aichen Wang , Junwen Bai , Zhiming Guo

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引用次数: 0

Abstract

Terahertz (THz) waves have demonstrated substantial potential for applications across various fields over more than three decades of development. In particular, THz spectroscopy has emerged as a powerful tool for biochemical detection due to its non-invasive and label-free capability to qualitatively and quantitatively analyze molecular properties. In the development of THz biochemical sensing technology, novel materials, exquisite device architectures, and optimized detection methods have been proposed to overcome performance limitations and broaden their range of applications. To comprehensively sort out these important technological breakthroughs made in recent years, this review is devoted to the main development process and typical application research, mainly including the following aspects of direct substance detection via THz sensing technology, metamaterial-based THz sensing and THz molecular fingerprint sensing. Finally, a summary and future directions for terahertz biochemical sensing technology are presented.

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太赫兹生物化学传感技术的最新进展：原理、发展与应用

在三十多年的发展中，太赫兹（THz）波已经显示出在各个领域应用的巨大潜力。特别是，太赫兹光谱由于其无创和无标记的能力，可以定性和定量地分析分子性质，已成为生物化学检测的有力工具。在太赫兹生物化学传感技术的发展中，提出了新型材料、精致的器件结构和优化的检测方法，以克服性能限制并扩大其应用范围。为全面梳理近年来取得的这些重要技术突破，本文对太赫兹传感技术的主要发展过程和典型应用研究进行了综述，主要包括太赫兹传感技术直接物质检测、基于超材料的太赫兹传感和太赫兹分子指纹传感三个方面。最后，对太赫兹生物化学传感技术进行了总结和展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.