Repetitive transcranial magnetic stimulation for musculoskeletal pain: A systematic review and meta-analysis.

IF 1.3 Q4 CLINICAL NEUROLOGY

British Journal of Pain Pub Date : 2025-07-01 DOI:10.1177/20494637251356812

Yanan Liang, Shuangyang Niu, Yonghui Wang

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引用次数: 0

Abstract

Objective: In this study, a meta-analysis was conducted to characterize the therapeutic benefits of repetitive transcranial magnetic stimulation (rTMS) on musculoskeletal (MSK) pain and potential factors affecting the effect.

Methods: A comprehensive search was performed in PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov for randomized and sham-controlled trials published from inception to 13 March 2024. We conducted this meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Based on the heterogeneity among studies, fixed effects or random-effects model was used for the effective analysis of rTMS on pain, quality of life, and depression.

Results: A total of 23 eligible randomized controlled trials (RCTs) comprising 1158 patients were included in our systematic search. The analysis showed effect sizes of -0.94 (95% CI: -1.30 to -0.59), indicating that real rTMS was better than sham stimulation in reducing pain (p < 0.01). Also, rTMS reduced depression scores and improved follow-up effects and the quality of life of MSK pain patients. In the subgroup analysis, stimulation frequency, intensity, and session frequency were important factors affecting the therapeutic effect.

Conclusions: Our review demonstrated that rTMS had the potential to relieve pain and depression, enhance the quality of life for patients with MSK pain. Stimulation frequency, intensity, and session frequency were important factors affecting the therapeutic effect.

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重复经颅磁刺激治疗肌肉骨骼疼痛：一项系统回顾和荟萃分析。

目的：本研究对重复性经颅磁刺激（rTMS）治疗肌肉骨骼（MSK）疼痛的疗效及影响效果的潜在因素进行meta分析。方法：在PubMed、Web of Science、Embase、Cochrane Library和ClinicalTrials.gov网站上全面检索从开始到2024年3月13日发表的随机和假对照试验。我们按照系统评价和荟萃分析的首选报告项目进行了这项荟萃分析。基于研究间的异质性，采用固定效应或随机效应模型对rTMS对疼痛、生活质量和抑郁的影响进行有效分析。结果：我们的系统检索共纳入了23项符合条件的随机对照试验（RCTs），包括1158例患者。分析显示效应值为-0.94 (95% CI: -1.30 ~ -0.59)，表明真实rTMS在减轻疼痛方面优于假刺激（p < 0.01）。rTMS还能降低MSK疼痛患者的抑郁评分，改善随访效果和生活质量。在亚组分析中，刺激频率、强度和会话频率是影响治疗效果的重要因素。结论：我们的综述表明，rTMS有可能缓解疼痛和抑郁，提高MSK疼痛患者的生活质量。刺激频率、强度和疗程频率是影响治疗效果的重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Pain CLINICAL NEUROLOGY-

CiteScore

3.20

自引率

11.10%

发文量

期刊介绍： British Journal of Pain is a peer-reviewed quarterly British journal with an international multidisciplinary Editorial Board. The journal publishes original research and reviews on all major aspects of pain and pain management. Reviews reflect the body of evidence of the topic and are suitable for a multidisciplinary readership. Where empirical evidence is lacking, the reviews reflect the generally held opinions of experts in the field. The Journal has broadened its scope and has become a forum for publishing primary research together with brief reports related to pain and pain interventions. Submissions from all over the world have been published and are welcome. Official journal of the British Pain Society.