Exploring the Relationship between Extended Red Blood Cell Indices and Platelet Indices in Voluntary Blood Donors.

IF 1.8 Q3 MEDICAL LABORATORY TECHNOLOGY
Ranita De, Marballi Basavaraju Deepak, Leo Stephen, Kavitha Lakshmi, Joy Mammen, Eunice Sindhuvi Edison
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引用次数: 0

Abstract

Background: As regular blood donors are prone to iron deficiency, the importance of extended red blood cell (eRBC) indices in identifying donors with depleted iron stores was investigated. Thrombocytosis has been well documented in patients affected with iron deficiency anemia. Thus, the significance of eRBC indices in reflecting elevated platelet counts associated with nonanemic iron deficiency was examined in this cohort.

Methods: Blood samples were collected in EDTA tubes from consenting donors for analyses of routine hematological and eRBC indices. Serum samples were separated for the estimation of iron parameters.

Results: Iron-deficient donors had significantly altered eRBC indices. Among them, reticulocyte hemoglobin equivalent (Ret-He) with a cut-off of ≥32 pg had an area under the receiver operating characteristic curve (AUC) of 0.822 and showed a sensitivity of 72.5% and a specificity of 77.8% (P < 0.001) in detecting iron deficiency. The combination of Ret-He with combined cell index (CCI) (AUC = 0.825; 66% sensitivity, 91.9% specificity) increased sensitivity and specificity to 90.6% and 98.2%, respectively, in detecting donors affected with iron-restricted erythropoiesis. This cohort had increased platelet counts that showed significant association with Ret-He (b = -0.373, P = 0.007), red blood cell hemoglobin equivalent (b = -0.384, P = 0.005), CCI (b = 0.384, P = 0.006), percentage of red blood cells with mean corpuscular hemoglobin < 17 pg (b = 0.494, P < 0.001), and percentage of red blood cells with mean corpuscular volume < 60 fL (b = 0.299, P < 0.05).

Conclusions: eRBC indices are useful indicators of nonanemic iron deficiency, which may be enhanced by combining them. A significant relationship between platelet counts and eRBC indices in iron-deficient donors emerges, which has not been explored before.

探讨无偿献血者扩展红细胞指数与血小板指数的关系。
背景:由于定期献血者容易缺铁,因此研究了扩展红细胞(eRBC)指数在识别缺铁献血者中的重要性。血小板增多症在缺铁性贫血患者中有很好的记录。因此,eRBC指数在反映与非贫血性缺铁相关的血小板计数升高方面的意义在本队列中得到了检验。方法:采用EDTA管采集自愿献血者血样,分析血液学常规及eRBC指标。分离血清样品用于铁参数的估计。结果:缺铁供者eRBC指数明显改变。其中网红细胞血红蛋白当量(Ret-He)截断值≥32 pg,受者工作特征曲线下面积(AUC)为0.822,检测缺铁的敏感性为72.5%,特异性为77.8% (P < 0.001)。Ret-He与联合细胞指数(CCI)的结合(AUC = 0.825;(66%的敏感性,91.9%的特异性)在检测受铁限制红细胞的供者时,敏感性和特异性分别提高到90.6%和98.2%。该队列的血小板计数增加,与rett - he (b = -0.373, P = 0.007)、红细胞血红蛋白当量(b = -0.384, P = 0.005)、CCI (b = 0.384, P = 0.006)、平均红细胞血红蛋白< 17 pg的红细胞百分比(b = 0.494, P < 0.001)和平均红细胞体积< 60 fL的红细胞百分比(b = 0.299, P < 0.05)显著相关。结论:eRBC指标是诊断非贫血性缺铁的有效指标,两者联合使用可提高其诊断效果。在缺铁供者中,血小板计数和eRBC指数之间出现了显著的关系,这在以前没有被探索过。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Applied Laboratory Medicine
Journal of Applied Laboratory Medicine MEDICAL LABORATORY TECHNOLOGY-
CiteScore
3.70
自引率
5.00%
发文量
137
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