Gene polymorphisms associated with immunosuppression and their implications in the onset of cervical cancer.

IF 1.4 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Women & Health Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI:10.1080/03630242.2025.2525282

Adriano M F Aranome, Ana P L Pereira, Nádia C M Okuyama, Kleber P Trugilo, Michelle M Sena, Rodolfo S Ferreira, Fernando Cezar-Dos-Santos, José O Couto-Filho, Janaina N Oliveira, Eliza P Castilha, Rafaela R J Curti, Sara Mataroli de Godoy, Wilson Frantine-Silva, Roberta L Guembarovski, Karen B de Oliveira

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引用次数: 0

Abstract

The immune system plays a crucial role in determining the resolution or development of cervical pre-malignant lesions that culminate in cervical cancer (CC). A microenvironment with low inflammatory patterns is often associated with a worse prognosis.

Aim: To evaluate polymorphisms rs3087465 in the TGFBR2 and rs3761548 in the FOXP3 genes, as well as sociodemographic, reproductive, and sexual behavior data which may be associated with CC development.

Methods: In this cross-sectional case-control study conducted in the northern region of Paraná, Brazil, 134 women (41 cervical cancer patients and 93 controls) were recruited from public health services. DNA samples were extracted from cervical cells, peripheral blood, and tumor tissues and subjected to PCR for confirmation of HPV presence and subsequent genotyping of TGFBR2 (rs3087465) and FOXP3 (rs3761548) polymorphisms.

Results: Women with limited HPV knowledge, low income, and infrequent preventive exams were at higher risk of CC. Smoking and high parity were also associated with increased risk. Notably, TGFBR2 rs3087465 AG/GG genotypes were initially associated with increased risk of CC development. However, these associations were attenuated after adjusting for confounding variables.

Conclusions: These findings suggest that understanding genetic, environmental, and behavioral factors is essential for the prevention and effective treatment of CC.

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与免疫抑制相关的基因多态性及其在宫颈癌发病中的意义。

免疫系统在决定最终导致宫颈癌（CC）的宫颈癌前病变的消退或发展中起着至关重要的作用。低炎症模式的微环境通常与较差的预后相关。目的：评估TGFBR2基因rs3087465多态性和FOXP3基因rs3761548多态性，以及可能与CC发生相关的社会人口学、生殖和性行为数据。方法：本横断面病例对照研究在巴西帕拉纳北部地区进行，从公共卫生服务部门招募134名妇女（41名宫颈癌患者和93名对照组）。从宫颈细胞、外周血和肿瘤组织中提取DNA样本，进行PCR确认HPV的存在，并随后进行TGFBR2 （rs3087465）和FOXP3 （rs3761548）多态性的基因分型。结果：HPV知识有限、收入低、不经常进行预防性检查的妇女患CC的风险较高，吸烟和高胎次也与风险增加有关。值得注意的是，TGFBR2 rs3087465 AG/GG基因型最初与CC发展风险增加相关。然而，在调整混杂变量后，这些关联减弱了。结论：研究结果表明，了解遗传、环境和行为因素对预防和有效治疗CC至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Women & Health Multiple-

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Women & Health publishes original papers and critical reviews containing highly useful information for researchers, policy planners, and all providers of health care for women. These papers cover findings from studies concerning health and illness and physical and psychological well-being of women, as well as the environmental, lifestyle and sociocultural factors that are associated with health and disease, which have implications for prevention, early detection and treatment, limitation of disability and rehabilitation.