The Interaction between miRNAs and 14-3-3ζ Protein in Different Diseases.

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2025-07-02 DOI:10.2174/0109298665377739250618153852

Ahmad Fazilat, Alireza Soleimani Mamalo, Salomeh Roshani, Somaieh Razmi, Mohammad Valilo

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引用次数: 0

Abstract

Members of the 14-3-3 protein family are involved in various cellular processes, including migration, angiogenesis, cell cycle, apoptosis, and signal transduction. Nevertheless, the 14-3-3 family possibly plays a fundamental role in the development of diseases and cancer by regulating various biological pathways. MicroRNAs (miRNAs) are mainly transcribed by RNA polymerase II (pol II), with only a few exceptions involving RNA polymerase III (pol III). They can control cell mechanisms through different pathways. miRNAs inhibit or destroy mRNAs by binding to them. They control intracellular mechanisms by binding to molecules such as the 14-3-3ζ protein. miRNAs play a role in regulating this protein, and by inducing or suppressing it, they contribute to either the development or the prevention of the diseases. Therefore, considering the importance of the 14-3-3ζ protein in different pathways within the body, we decided to investigate the relationship between miRNAs and 14-3-3ζ and clarify their interactions, in this review.

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mirna与14-3-3ζ蛋白在不同疾病中的相互作用

14-3-3蛋白家族成员参与多种细胞过程，包括迁移、血管生成、细胞周期、凋亡和信号转导。然而，14-3-3家族可能通过调节多种生物学途径，在疾病和癌症的发展中发挥着重要作用。MicroRNAs （miRNAs）主要由RNA聚合酶II （pol II）转录，只有少数例外涉及RNA聚合酶III （pol III）。它们可以通过不同的途径控制细胞机制。mirna通过与mrna结合来抑制或破坏它们。它们通过与14-3-3ζ蛋白等分子结合来控制细胞内机制。mirna在调节这种蛋白中发挥作用，通过诱导或抑制它，它们有助于疾病的发展或预防。因此，考虑到14-3-3ζ蛋白在体内不同途径中的重要性，我们决定在这篇综述中研究mirna与14-3-3ζ之间的关系，并阐明它们之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis