Tripartite interplay: immune reconstitution dynamics in AIDS, gut microbiota, and Helicobacter pylori infection: current advances and therapeutic prospects.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-07-03 DOI:10.1186/s13099-025-00726-z

Jingjing He, Shengkui Tan, Jiannan Lv

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引用次数: 0

Abstract

Background: The immune recovery process in Acquired Immune Deficiency Syndrome (AIDS) is complex and influenced by numerous factors. Gut microbiota and their metabolites play a critical role in maintaining immune homeostasis. Additionally, the presence of Helicobacter pylori in the stomach can affect immune reconstitution in human immunodeficiency virus (HIV)/AIDS patients, either directly or through interactions with the gut microbiota.

Methods: This review adopts a comprehensive literature review approach. It systematically examines a wide range of relevant studies focusing on the interplay between HIV/AIDS immune reconstitution, gut microbiota, and H. pylori.

Results: The review reveals intricate relationships among these components. Gut microbiota and their metabolites are essential for sustaining immune balance. H. pylori influences immune reconstitution in HIV/AIDS patients through various mechanisms, including inducing gut microbiota dysbiosis, altering gastric pH, promoting systemic inflammation, and acting synergistically with HIV. These effects can exacerbate CD4⁺ T cell depletion and may contribute to incomplete immune recovery by disrupting gut microbiota composition.

Conclusion: Understanding these interactions provides a foundation for future research directions. Such insights may offer new perspectives and strategies to address the clinical challenge of immunological non-response in HIV/AIDS patients.

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三方相互作用：艾滋病、肠道菌群和幽门螺杆菌感染的免疫重建动力学：目前的进展和治疗前景。

背景：获得性免疫缺陷综合征（AIDS）患者的免疫恢复过程复杂，受多种因素影响。肠道菌群及其代谢产物在维持免疫稳态中起着至关重要的作用。此外，胃中幽门螺杆菌的存在可以直接或通过与肠道微生物群的相互作用影响人类免疫缺陷病毒(HIV)/艾滋病患者的免疫重建。方法：本文采用综合文献复习法。它系统地检查了广泛的相关研究，重点是艾滋病毒/艾滋病免疫重建，肠道微生物群和幽门螺杆菌之间的相互作用。结果：综述揭示了这些成分之间错综复杂的关系。肠道菌群及其代谢产物对维持免疫平衡至关重要。幽门螺旋杆菌通过多种机制影响HIV/AIDS患者的免疫重建，包括诱导肠道菌群失调、改变胃pH值、促进全身性炎症以及与HIV协同作用。这些影响会加剧CD4 + T细胞耗竭，并可能通过破坏肠道微生物群组成导致不完全的免疫恢复。结论：了解这些相互作用为今后的研究方向奠定了基础。这些见解可能为解决艾滋病毒/艾滋病患者免疫无反应的临床挑战提供新的视角和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).