Dietary supplementation with fermented rapeseed and seaweed modulates parasite infections and gut microbiota in outdoor pigs.

IF 2.6 2区 农林科学 Q1 VETERINARY SCIENCES
Frontiers in Veterinary Science Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1565686
Charlotte Smith Bonde, Frida Brasen Drøhse, Nilay Büdeyri Gökgöz, Lukasz Krych, Dennis Sandris Nielsen, Heidi Huus Petersen, Rikke Matthiesen, Ninfa Rangel Pedersen, Peter Geldhof, Andrew R Williams, Stig Milan Thamsborg, Helena Mejer
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引用次数: 0

Abstract

Outdoor pig production systems can increase exposure to helminth infections such as Ascaris suum. Anthelmintic drug treatments are currently the primary strategy for controlling such infections; however, this approach is considered unsustainable due to the risk of parasites developing anthelmintic resistance. This study investigated the potential anthelmintic effect of a 2% w/w fermented rapeseed-seaweed (FRS) dietary supplement administered over an 11-12 week period in growing-finisher pigs. Outcomes assessed included parasitic fecal egg counts (FEC), serology, gut microbiota composition, and systemic inflammation. The FRS supplement consisted of 6% Saccharina latissima, 6% Ascophyllum nodosum, and 88% rapeseed meal (based on dry matter) and was provided in two different batches. Supplementation with FRS tended to lower FEC and reduce the incidence of A. suum infection. However, this effect varied between batches. FRS also influenced gut microbiota composition: pigs that were fed the second batch of FRS showed an increased relative abundance of several Bacteroidetes members (e.g., Prevotella), while unsupplemented pigs were enriched with various taxa from the Firmicutes phylum, such as Clostridium spp. Furthermore, pigs fed the second batch of FTR showed reduced daily weight gain compared to those fed the control diet. Overall, our results indicate that FRS modulates the gut microbiota toward a composition potentially associated with improved gut health and may have promise as a prebiotic or novel feed additive to help reduce helminth infections.

饲粮中添加发酵油菜籽和海藻可调节户外猪的寄生虫感染和肠道微生物群。
室外养猪系统会增加暴露于蠕虫感染,如猪蛔虫。驱虫药治疗目前是控制这类感染的主要策略;然而,这种方法被认为是不可持续的,因为寄生虫有产生抗虫性的风险。本研究研究了在生长育肥猪饲粮中添加2% w/w的发酵油菜籽海藻(FRS)的潜在驱虫效果,为期11-12周。评估的结果包括寄生粪卵计数(FEC)、血清学、肠道微生物群组成和全身炎症。FRS添加物由6%的糖精、6%的藤属植物和88%的油菜籽粕(以干物质为基础)组成,分两批提供。补充FRS可降低FEC,降低猪链球菌感染的发生率。然而,这种效果在批次之间有所不同。FRS还影响了肠道微生物群的组成:饲喂第二批FRS的猪显示出几种拟杆菌门成员(如普雷沃氏菌)的相对丰度增加,而未添加FRS的猪则富含厚壁菌门的各种分类群,如梭状芽孢杆菌。此外,饲喂第二批FRS的猪与饲喂对照日粮的猪相比,日增重降低。总的来说,我们的研究结果表明,FRS调节肠道微生物群的组成可能与改善肠道健康有关,并且可能有希望作为益生元或新型饲料添加剂来帮助减少蠕虫感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Veterinary Science
Frontiers in Veterinary Science Veterinary-General Veterinary
CiteScore
4.80
自引率
9.40%
发文量
1870
审稿时长
14 weeks
期刊介绍: Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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