Aerobic exercise decreases interstitial glucose concentrations up to 2 h after exercise in dogs with insulin-treated diabetes mellitus: a preliminary study.

IF 2.6 2区 农林科学 Q1 VETERINARY SCIENCES
Frontiers in Veterinary Science Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1595952
Jessica R Mampe, Darko Stefanovski, Rebecka S Hess
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引用次数: 0

Abstract

Introduction: The effect of aerobic exercise on glucose concentration has been reported in healthy normal and over-conditioned dogs and in experimental dog models. However, the effect of aerobic exercise on interstitial glucose concentration (IG) has not been reported in dogs with insulin-treated naturally-occurring diabetes mellitus.

Objective: Determine if aerobic exercise decreases IG in outpatient diabetic dogs.

Methods: Five NPH insulin-treated client-owned diabetic dogs were prospectively enrolled into this interventional longitudinal cohort study. Dogs with a flash glucose monitoring system performed once daily aerobic exercise over 30 min for 7 consecutive days, if IG was 60 mg/dL during the preceding 12 h of observation. Dogs weighing <10 kg exercised (walked or jogged) for 1.5-2 miles, dogs 10-20 kg exercised for 2-2.5 miles, and dogs >20 kg exercised for 2.5-3 miles. Multivariable mixed-effects linear regression models followed by post-hoc analyses were used to estimate the marginal mean differences between IG 0.5, 1, 1.5, 2, and 4 h after exercise compared with marginal mean baseline IG measured twice over 30 min just before each daily exercise period, which served as the control.

Results: Marginal means (95% confidence intervals) of IG were significantly lower 1.5 h after exercise [188 mg/dL (96-281 mg/dL)] and 2 h after exercise [185 mg/dL (82-287 mg/dL)] compared with marginal mean IG measured just before exercise [223 mg/dL (129-317 mg/dL, p = 0.03, p = 0.008, respectively)]. Marginal means of IG were not significantly different 4 h after exercise compared with marginal mean IG measured just before exercise.

Conclusion: Our preliminary data suggest that aerobic exercise may reduce IG levels up to two hours following exercise. These findings indicate that exercise could potentially serve as an adjunct approach to managing insulin-treated diabetic dogs in a home setting.

有氧运动使胰岛素治疗的糖尿病狗运动后间质葡萄糖浓度降低2 h:一项初步研究。
导读:有氧运动对血糖浓度的影响已经在健康的正常和过度条件狗和实验狗模型中报道过。然而,有氧运动对胰岛素治疗的天然糖尿病犬间质糖浓度(IG)的影响尚未见报道。目的:确定有氧运动是否能降低门诊糖尿病犬的IG。方法:5只接受NPH胰岛素治疗的糖尿病犬被前瞻性地纳入这项干预性纵向队列研究。如果在观察前12 小时IG≥60 mg/dL,使用瞬时血糖监测系统的狗连续7天每天进行一次30 min的有氧运动。体重20 公斤的狗锻炼2.5-3 英里。采用多变量混合效应线性回归模型进行事后分析,估计运动后IG 0.5、1、1.5、2和4 h与每天运动前30 min测量两次IG的边际平均基线差异,以作为对照。结果:搞笑的边际意味着(95%置信区间)显著降低1.5 h运动后[188 mg / dL (96 - 281 mg / dL )]和2 h运动后[185 mg / dL (82 - 287 mg / dL )]与边际的意思是搞笑测量运动前[223 mg / dL (129 - 317 mg / dL ,p = 0.03,p = 0.008)]。运动后IG的边际均值与运动前IG的边际均值无显著差异4 h。结论:我们的初步数据表明,有氧运动可以在运动后2小时内降低IG水平。这些发现表明,运动可能作为一种辅助方法,在家庭环境中管理胰岛素治疗的糖尿病狗。
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来源期刊
Frontiers in Veterinary Science
Frontiers in Veterinary Science Veterinary-General Veterinary
CiteScore
4.80
自引率
9.40%
发文量
1870
审稿时长
14 weeks
期刊介绍: Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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