Aerobic exercise decreases interstitial glucose concentrations up to 2 h after exercise in dogs with insulin-treated diabetes mellitus: a preliminary study.
Jessica R Mampe, Darko Stefanovski, Rebecka S Hess
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引用次数: 0
Abstract
Introduction: The effect of aerobic exercise on glucose concentration has been reported in healthy normal and over-conditioned dogs and in experimental dog models. However, the effect of aerobic exercise on interstitial glucose concentration (IG) has not been reported in dogs with insulin-treated naturally-occurring diabetes mellitus.
Objective: Determine if aerobic exercise decreases IG in outpatient diabetic dogs.
Methods: Five NPH insulin-treated client-owned diabetic dogs were prospectively enrolled into this interventional longitudinal cohort study. Dogs with a flash glucose monitoring system performed once daily aerobic exercise over 30 min for 7 consecutive days, if IG was 60 mg/dL during the preceding 12 h of observation. Dogs weighing <10 kg exercised (walked or jogged) for 1.5-2 miles, dogs 10-20 kg exercised for 2-2.5 miles, and dogs >20 kg exercised for 2.5-3 miles. Multivariable mixed-effects linear regression models followed by post-hoc analyses were used to estimate the marginal mean differences between IG 0.5, 1, 1.5, 2, and 4 h after exercise compared with marginal mean baseline IG measured twice over 30 min just before each daily exercise period, which served as the control.
Results: Marginal means (95% confidence intervals) of IG were significantly lower 1.5 h after exercise [188 mg/dL (96-281 mg/dL)] and 2 h after exercise [185 mg/dL (82-287 mg/dL)] compared with marginal mean IG measured just before exercise [223 mg/dL (129-317 mg/dL, p = 0.03, p = 0.008, respectively)]. Marginal means of IG were not significantly different 4 h after exercise compared with marginal mean IG measured just before exercise.
Conclusion: Our preliminary data suggest that aerobic exercise may reduce IG levels up to two hours following exercise. These findings indicate that exercise could potentially serve as an adjunct approach to managing insulin-treated diabetic dogs in a home setting.
期刊介绍:
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.