Prognostic role of miR-190, miR-221, and miR-381 in breast cancer: a systematic review and meta-analysis.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-06-01 DOI:10.26355/eurrev_202506_37272

S Matsas, A Ruiz Simões, P Nazareth Aguiar, Y Abdou, H Krontiras, A Del Giglio

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引用次数: 0

Abstract

OBJECTIVE: Breast cancer is the most frequently diagnosed malignancy in women and a leading cause of cancer-related mortality. Conventional prognostic tools may not fully capture disease outcomes. MicroRNA (miR) expression has emerged as a potential prognostic factor, though findings remain inconsistent. This systematic review and meta-analysis assess the prognostic role of miR-190, miR-221, and miR-381 in predicting overall survival (OS) among breast cancer patients. MATERIALS AND METHODS: A comprehensive literature search in PubMed, Embase, and Scopus identified relevant studies. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the relationship between miR expression and OS. Subgroup analyses were conducted to explore potential sources of heterogeneity. RESULTS: Four studies on miR-221, four on miR-190, and three on miR-381 met inclusion criteria. High miR-190 expression was significantly associated with improved OS (HR: 0.63; 95% CI: 0.47-0.84), as was miR-381 (HR: 0.64; 95% CI: 0.52-0.79). No significant association was found between miR-221 expression and OS (HR: 1.12; 95% CI: 0.86-1.46). Subgroup analysis reinforced these findings, and Newcastle-Ottawa scale assessment indicated low publication bias in 10 out of 11. CONCLUSIONS: Elevated miR-190 and miR-381 levels are associated with improved OS in breast cancer, whereas the prognostic role of miR-221 remains unclear. These findings underscore the potential of miR-190 and miR-381 as prognostic biomarkers.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-18-scaled.jpg.

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miR-190、miR-221和miR-381在乳腺癌中的预后作用：一项系统综述和荟萃分析

目的：乳腺癌是女性中最常见的恶性肿瘤，也是癌症相关死亡的主要原因。传统的预后工具可能无法完全捕捉疾病的结果。MicroRNA （miR）表达已成为潜在的预后因素，尽管研究结果仍不一致。本系统综述和荟萃分析评估了miR-190、miR-221和miR-381在预测乳腺癌患者总生存期（OS）中的预后作用。材料和方法：在PubMed， Embase和Scopus中进行综合文献检索，确定相关研究。计算合并风险比（hr）和95%置信区间（ci）来评估miR表达与OS之间的关系。进行亚组分析以探索异质性的潜在来源。结果：4项关于miR-221的研究，4项关于miR-190的研究，3项关于miR-381的研究符合纳入标准。miR-190高表达与OS改善显著相关(HR: 0.63；95% CI: 0.47-0.84)， miR-381也是如此(HR: 0.64；95% ci: 0.52-0.79)。miR-221表达与OS无显著相关性(HR: 1.12；95% ci: 0.86-1.46)。亚组分析强化了这些发现，纽卡斯尔-渥太华量表评估显示，11篇文章中有10篇的发表偏倚较低。结论：miR-190和miR-381水平升高与乳腺癌OS改善相关，而miR-221在预后中的作用尚不清楚。这些发现强调了miR-190和miR-381作为预后生物标志物的潜力。图形摘要：https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-18-scaled.jpg。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)