Effects of benign ovarian cyst volume and laterality on AMH and CA-125 levels.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

BMC Women's Health Pub Date : 2025-07-04 DOI:10.1186/s12905-025-03842-9

Aykut Kından, Aziz Kından, Ahmet Kurt, Volkan Özgür Akbulut, Berna Dilbaz

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Abstract

Objective: This study aimed to investigate the effects of cyst volume and bilaterality on serum Anti-Müllerian Hormone (AMH) and CA-125 levels in patients with benign ovarian cysts.

Methods: We retrospectively analyzed 139 patients who underwent cystectomy for benign ovarian cysts. Serum AMH and CA-125 levels were measured preoperatively and at the second post-operative month.

Results: The mean preoperative AMH level was 3.96 ± 3.48 ng/mL, which significantly decreased to 3.59 ± 3.92 ng/mL postoperatively (p = 0.026), reflecting an average decline of 9.3%. CA-125 levels significantly decreased from 53.1 ± 157.2 to 21.0 ± 18.4 U/mL (p = 0.002). Patients with bilateral cysts had lower AMH levels at the second month (1.67 ± 0.6 vs. 3.80 ± 4.1 ng/mL; p = 0.003) despite similar baseline values.

Conclusion: Bilaterality and cyst volume may negatively affect ovarian reserve postoperatively. The decline in AMH levels, particularly following bilateral ovarian cystectomy, has a significant impact on the ovarian reserve and may have implications for future fertility. Early fertility counselling and ovarian preservation strategies should be considered during surgical planning.

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良性卵巢囊肿体积和侧位对AMH和CA-125水平的影响。

目的：探讨囊肿体积和双侧性对良性卵巢囊肿患者血清抗勒氏激素（AMH）和CA-125水平的影响。方法：回顾性分析139例良性卵巢囊肿切除术患者。术前和术后第二个月分别测定血清AMH和CA-125水平。结果：术前AMH均值为3.96±3.48 ng/mL，术后AMH均值为3.59±3.92 ng/mL，差异有统计学意义（p = 0.026），平均下降9.3%。CA-125水平由53.1±157.2降至21.0±18.4 U/mL （p = 0.002）。双侧囊肿患者在第二个月AMH水平较低(1.67±0.6比3.80±4.1 ng/mL；P = 0.003)，尽管基线值相似。结论：双侧性和囊肿体积对术后卵巢储备有不利影响。AMH水平的下降，特别是在双侧卵巢囊肿切除术后，对卵巢储备有重大影响，并可能对未来的生育能力产生影响。在手术计划中应考虑早期生育咨询和卵巢保存策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.40

自引率

4.00%

发文量

444

审稿时长

>12 weeks

期刊介绍： BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.