{"title":"Gut-breast axis modulation through Streptococcus thermophilus TCI633 supplementation: a study on mother-infant microbiome dynamics.","authors":"C-C Chen, T-Y Lin, W-K Wu, S Panyod, Y-K Lin, Y-H Lin, S-T Chan, M-S Wu, C-N Lee, C-F Chiang","doi":"10.1163/18762891-bja00082","DOIUrl":null,"url":null,"abstract":"<p><p>Breast milk provides essential nutrition and bioactive components, including probiotics, which contribute to the development of a balanced infant microbiota and a strengthened immune system. The gut-breast axis theory suggests that the maternal gut microbiota may influence the microbiota and composition of breast milk through immune-mediated signaling. This study aimed to investigate the colonization potential of S. thermophilus TCI633 in the infant gut and to explore its possible transfer via the gut-breast axis. A total of 30 exclusively breastfeeding mother-infant pairs were recruited. Mothers took TCI633 daily for one month following hospital discharge. Breast milk, maternal feces, and infant fecal samples were collected and analyzed for microbiota composition, S. thermophilus abundance, and detection of TCI633-specific gene fragments. Results showed minor changes in the microbiota composition of breast milk and fecal samples in the TCI633 group, with a slight increase in S. thermophilus abundance. Furthermore, TCI633-specific gene fragments were detected in 66.7% of infant fecal samples, suggesting potential microbial transfer and colonisation. These findings provide preliminary evidence supporting the feasibility of TCI633 transmission via the gut-breast axis, although further research is needed to determine its functional significance.</p>","PeriodicalId":8834,"journal":{"name":"Beneficial microbes","volume":" ","pages":"1-8"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Beneficial microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1163/18762891-bja00082","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Breast milk provides essential nutrition and bioactive components, including probiotics, which contribute to the development of a balanced infant microbiota and a strengthened immune system. The gut-breast axis theory suggests that the maternal gut microbiota may influence the microbiota and composition of breast milk through immune-mediated signaling. This study aimed to investigate the colonization potential of S. thermophilus TCI633 in the infant gut and to explore its possible transfer via the gut-breast axis. A total of 30 exclusively breastfeeding mother-infant pairs were recruited. Mothers took TCI633 daily for one month following hospital discharge. Breast milk, maternal feces, and infant fecal samples were collected and analyzed for microbiota composition, S. thermophilus abundance, and detection of TCI633-specific gene fragments. Results showed minor changes in the microbiota composition of breast milk and fecal samples in the TCI633 group, with a slight increase in S. thermophilus abundance. Furthermore, TCI633-specific gene fragments were detected in 66.7% of infant fecal samples, suggesting potential microbial transfer and colonisation. These findings provide preliminary evidence supporting the feasibility of TCI633 transmission via the gut-breast axis, although further research is needed to determine its functional significance.
期刊介绍：
Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators.
The journal will have five major sections:
* Food, nutrition and health
* Animal nutrition
* Processing and application
* Regulatory & safety aspects
* Medical & health applications
In these sections, topics dealt with by Beneficial Microbes include:
* Worldwide safety and regulatory issues
* Human and animal nutrition and health effects
* Latest discoveries in mechanistic studies and screening methods to unravel mode of action
* Host physiology related to allergy, inflammation, obesity, etc.
* Trends in application of (meta)genomics, proteomics and metabolomics
* New developments in how processing optimizes pro- & prebiotics for application
* Bacterial physiology related to health benefits
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