Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D.

IF 3 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sandra Rodrigues Xavier, Isabelle Caroline Dos Santos Barcelos, Isadora Braga Gandra, Sabrina Paula Pereira, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Lucas da Silva Lopes, Rafaela Camargo Rodrigues Machado, Leonardo Maciel Santos Silva, Líria Souza Silva, Lívia Corrêa Ferreira, Luiz Fellype Alves de Souza, Rutilene Barbosa Souza, Ana Maísa Passos-Silva, Mariana Campos da Paz, Miguel Angel Chávez Fumagalli, Eduardo Antônio Ferraz Coelho, Rodolfo Cordeiro Giunchetti, Juliana Martins Machado, Ana Alice Maia Gonçalves, Soraya Dos Santos Pereira, Daniel Archimedes da Matta, Deusilene Souza Vieira, Alexsandro Sobreira Galdino
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引用次数: 0

Abstract

Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care. Recombinant proteins (RP), recombinant multiepitope proteins (RMP), and synthetic peptides have been extensively reported as tools for efficient immunodiagnosis of several diseases. This review aimed to discuss the use of these antigens for the immunodiagnosis of HD. To this end, a bibliographic study was conducted in the PubMed database by searching the primary ("Hepatitis D" and "Hepatitis Delta"), secondary ("Detection", "Diagno*", "Diagnosis", "Immunodiagnosis", and "Serodiagnosis"), and tertiary ("Chimera", "Epitope", "Peptide"; "Protein" and "Recombinant") descriptors, including papers published up to January 2025. Review articles and case reports were excluded. Only nine articles (five for RP, three for synthetic peptides, and one for RMP) met the inclusion criteria, revealing that there are very few studies on this subject, particularly when compared to the advances made in the diagnosis of hepatitis A, B, and C. Despite the scarcity of articles published in the literature, six of the nine analyzed studies corroborate the potential of these antigens to effectively replace traditional diagnostic methods, including development of rapid tests. These data highlight the need for further studies to assess the potential of RP, RMP, and synthetic peptides for immunodiagnosis of HD, aiming to increase the accuracy of diagnosis, as well as improve monitoring and prevention.

蛋白质和多肽作为D型肝炎免疫诊断的候选抗原。
设计创新的、准确的、普遍的和可获得的诊断检测是改善丁型肝炎筛查、预防和管理的必要条件,特别是在基础设施差和获得公共卫生保健机会有限的流行地区。重组蛋白(RP)、重组多表位蛋白(RMP)和合成肽已被广泛报道为多种疾病的有效免疫诊断工具。本综述旨在讨论这些抗原在HD免疫诊断中的应用。为此,我们在PubMed数据库中检索了一级(“丁型肝炎”和“丁型肝炎”)、二级(“检测”、“诊断”、“免疫诊断”和“血清诊断”)和三级(“嵌合体”、“表位”、“肽”;“蛋白质”和“重组”)描述符,包括截至2025年1月发表的论文。综述文章和病例报告被排除在外。只有9篇文章(5篇关于RP, 3篇关于合成肽,1篇关于RMP)符合纳入标准,这表明关于这一主题的研究很少,特别是与甲型、乙型和丙型肝炎诊断方面的进展相比。尽管文献中发表的文章很少,但9项分析研究中有6项证实了这些抗原有效取代传统诊断方法的潜力,包括快速检测的发展。这些数据表明,有必要进一步研究RP、RMP和合成肽在HD免疫诊断中的潜力,以提高诊断的准确性,并改善监测和预防。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Amino Acids
Amino Acids 生物-生化与分子生物学
CiteScore
6.40
自引率
5.70%
发文量
99
审稿时长
2.2 months
期刊介绍: Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology
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