Survival, efficacy and organ preservation outcomes of induction chemotherapy in sinonasal squamous cell carcinoma: a systematic review and meta-analysis.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2025-07-03 DOI:10.1080/00016489.2025.2520320

Srivatsa Surya Vasudevan, Nrusheel Kattar, Morni Modi, Manish D Mair, Ameya A Asarkar

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引用次数: 0

Abstract

Background: Locally advanced sinonasal squamous cell carcinoma (SNSCC) is typically treated with surgery, adjuvant radiation, and possibly chemotherapy, but the role of induction chemotherapy (ICT) has not been extensively studied.

Objective: The main objective was to assess the survival, efficacy, and organ preservation outcomes of ICT.

Material and methods: National Institute for Health and Care Excellence (NICE) search domain, PubMed, Embase, and Medline were queried for articles from inception through December 2024. A random-effects meta-analysis of pooled response, survival and orbital preservation rates were assessed.

Results: A total of 9 studies with 338 ICT patients were included. The pooled partial response (PR) rate was 57%. Complete response rates ranged from 2% to 17%, and stable response rates from 15% to 42%. Two-year overall survival was 78% (95% CI: 0.60-0.90) and disease-free survival was 93% (95% CI: 0.82-0.97). Orbital preservation rates were 83% (95% CI: 0.75-0.90).

Conclusions: Pooled evidence suggests that ICT may be an effective modality in producing PR for locally advanced SNSCC. However, high-quality trials with standardized regimens are needed to confirm its role.

Significance: This review provides the most updated statistical outcomes of ICT treatment in treating SNSCC which can help make decisions.

查看原文本刊更多论文

鼻窦鳞状细胞癌诱导化疗的生存、疗效和器官保存结果：系统回顾和荟萃分析。

背景：局部晚期鼻窦鳞状细胞癌（SNSCC）通常采用手术、辅助放疗和可能的化疗治疗，但诱导化疗（ICT）的作用尚未得到广泛研究。目的：主要目的是评估ICT的生存、疗效和器官保存结果。材料和方法：查询了国家健康与护理卓越研究所（NICE）搜索域、PubMed、Embase和Medline从成立到2024年12月的文章。随机效应荟萃分析评估了合并反应、生存率和眼眶保存率。结果：共纳入9项研究，338例ICT患者。合并部分缓解（PR）率为57%。完全缓解率从2%到17%，稳定缓解率从15%到42%。两年总生存率为78% (95% CI: 0.60-0.90)，无病生存率为93% （95% CI: 0.82-0.97）。眼眶保存率为83% （95% CI: 0.75-0.90）。结论：综合证据表明，ICT可能是局部晚期SNSCC产生PR的有效方式。然而，需要标准化方案的高质量试验来证实其作用。意义：本综述提供了ICT治疗SNSCC的最新统计结果，有助于决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.