Biodegradable chitosan/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications.

IF 4.3 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Abdelrhman Ragab, Nourhan El-Badry, Nouran Tamer, Ahmed Naas, Ahmed Hamdy, Samar H Tawakey, Abdelrahim H A Hassan, Alyaa I Salim
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Abstract

Chronic wounds pose significant healthcare challenges globally. The need for more effective strategies for wound healing applications has led to the exploration of numerous emerging technologies. The current study investigates the wound-healing potential of green synthesized silver nanoparticles (AgNPs) using Aloe Vera and green tea loaded on polyvinyl alcohol (PVA)/chitosan hydrogel. To this end, different hydrogel films incorporating various types of AgNPs were prepared. XRD, SEM, and EDX confirmed good integration of the crystallographic structure of the green synthesized nanomaterial and indicated smooth surface morphology of the films. The results of the biodegradability test showed that the Aloe Vera synthesized AgNPs hydrogel patch exhibited a high degradation rate with (22%) weight loss after 30 days. The results of in vitro antimicrobial testing and cytotoxicity assays revealed that Aloe Vera-synthesized AgNPs possess higher antibacterial activity against Escherichia coli and Staphylococcus aureus with high cell viability (82%). The in vitro release of AgNPs showed a gradual release of AgNPs with stabilization. The water vapor transmission rate was found to range between 1388.89 g/m2/day and a moisture content of 7.73%. The tensile stress and elongation at break were found to range between 69.14-67-13 MPa and 4.84%-4.34%, respectively, indicating significant mechanical properties of the films. Overall, the results proved that green synthesized AgNPs hydrogel patches, especially using Aloe Vera, provide the optimal properties for wound healing, combining good moisture utilization, stability, and holding potential as a biodegradable, antibacterial wound dressing.

可生物降解的壳聚糖/聚乙烯醇基水凝胶,结合绿色合成纳米银用于伤口愈合应用。
慢性伤口在全球范围内构成了重大的医疗保健挑战。对更有效的伤口愈合应用策略的需求导致了许多新兴技术的探索。本研究研究了芦荟和绿茶负载聚乙烯醇(PVA)/壳聚糖水凝胶的绿色合成银纳米粒子(AgNPs)的伤口愈合潜力。为此,制备了包含不同类型AgNPs的不同水凝胶膜。XRD、SEM和EDX证实了绿色合成纳米材料晶体结构的良好整合,并表明薄膜表面形貌光滑。生物降解性试验结果表明,芦荟合成的AgNPs水凝胶贴片具有较高的降解率,30 d后重量减轻22%。体外抗菌实验和细胞毒性实验结果表明,芦荟合成的AgNPs对大肠杆菌和金黄色葡萄球菌具有较高的抑菌活性,细胞存活率高达82%。AgNPs的体外释放表现为逐渐稳定释放。水蒸气透过率为1388.89 g/m2/d,含水率为7.73%。拉伸应力和断裂伸长率分别在69.14 ~ 67 ~ 13 MPa和4.84% ~ 4.34%之间,具有良好的力学性能。总体而言,研究结果证明,绿色合成AgNPs水凝胶贴剂,特别是使用芦荟的AgNPs水凝胶贴剂,具有良好的水分利用率、稳定性和保持潜力,是一种可生物降解的抗菌创面敷料,具有最佳的伤口愈合性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Chemistry
BMC Chemistry Chemistry-General Chemistry
CiteScore
5.30
自引率
2.20%
发文量
92
审稿时长
27 weeks
期刊介绍: BMC Chemistry, formerly known as Chemistry Central Journal, is now part of the BMC series journals family. Chemistry Central Journal has served the chemistry community as a trusted open access resource for more than 10 years – and we are delighted to announce the next step on its journey. In January 2019 the journal has been renamed BMC Chemistry and now strengthens the BMC series footprint in the physical sciences by publishing quality articles and by pushing the boundaries of open chemistry.
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