High-valued hexoses bioproduction from natural sugar resources: Status, trends, challenges and perspectives

IF 9.7 1区 环境科学与生态学 Q1 AGRICULTURAL ENGINEERING
Mengwei Lu , Na Li , Deming Rao , Jing Wu , Wei Xia
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Abstract

The high-valued conversion of natural sugar resources is one of the priorities for global resource utilization and human health development. These conversions can not only greatly improve the efficiency of carbon resource utilization, but its diversified products are also potential candidates for alleviating the increasingly serious human health problems such as obesity and diabetes. As a novel sugar food additive, the industrial-scale production of high-valued hexoses have emerged as a critical focus in food science and biotechnology. This study evaluates established methodologies for bioproduction of high-valued hexoses, and provides a comparative assessment of technological advantages and industrial scalability limitations. Our investigation highlights the thermodynamic-driven isomerization as a promising platform for industrial applications in theory, necessitating an in-depth examination of its current technological status and developmental prospects. The thermodynamic-driven isomerization demonstrates distinct thermodynamic advantages through its innovative energy-recycling mechanism, coupled with the utilization of cost-effective starch derivatives as substrates. However, three critical challenges hinder its industrial application: (1) Insufficient catalytic properties of rate-limiting enzymes; (2) Instability of continuous bioprocessing; (3) Suboptimal atomic economy. Strategic advancements should focus on: (1) Mining novel biocatalysts through integrated approaches combining structural bioinformatics, molecular dynamics simulations, and directed evolution; (2) Developing immobilized enzyme reactors with improved stability; (3) Residual substrate recycling and by-product minimization to improve atomic economy. These synergistic improvements have the potential to substantially improve hexose conversion while significantly reducing manufacturing costs, ultimately enabling cost-competitive industrial-scale functional sweetener production.

Abstract Image

利用天然糖资源生产高价值己糖:现状、趋势、挑战和展望。
天然糖资源的高价值转化是全球资源利用和人类健康发展的重点之一。这些转化不仅可以大大提高碳资源的利用效率,而且其多样化的产品也有可能缓解日益严重的人类健康问题,如肥胖和糖尿病。己糖作为一种新型的糖类食品添加剂,其产业化生产已成为食品科学和生物技术研究的热点。本研究评估了高价值己糖生物生产的既定方法,并提供了技术优势和工业可扩展性限制的比较评估。我们的研究强调了热力学驱动异构化在理论上是一个很有前途的工业应用平台,有必要对其目前的技术现状和发展前景进行深入研究。热力学驱动的异构化通过其创新的能量回收机制,以及利用具有成本效益的淀粉衍生物作为底物,显示出明显的热力学优势。然而,阻碍其工业应用的关键挑战有三个:(1)限速酶的催化性能不足;(2)连续生物处理的不稳定性;(3)次优原子经济。战略进展应集中在:(1)通过结合结构生物信息学、分子动力学模拟和定向进化的综合方法挖掘新型生物催化剂;(2)开发稳定性更高的固定化酶反应器;(3)残余衬底回收和副产物最小化,提高原子经济性。这些协同改进具有显著提高己糖转化率的潜力,同时显著降低制造成本,最终实现具有成本竞争力的工业规模功能性甜味剂生产。
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来源期刊
Bioresource Technology
Bioresource Technology 工程技术-能源与燃料
CiteScore
20.80
自引率
19.30%
发文量
2013
审稿时长
12 days
期刊介绍: Bioresource Technology publishes original articles, review articles, case studies, and short communications covering the fundamentals, applications, and management of bioresource technology. The journal seeks to advance and disseminate knowledge across various areas related to biomass, biological waste treatment, bioenergy, biotransformations, bioresource systems analysis, and associated conversion or production technologies. Topics include: • Biofuels: liquid and gaseous biofuels production, modeling and economics • Bioprocesses and bioproducts: biocatalysis and fermentations • Biomass and feedstocks utilization: bioconversion of agro-industrial residues • Environmental protection: biological waste treatment • Thermochemical conversion of biomass: combustion, pyrolysis, gasification, catalysis.
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