{"title":"The Role of m6A-RNA Methylation in the Development, Progression, and Treatment Response of Bladder Cancer","authors":"Tatiana Sinyagovskaya, Yuliya Li, Natalya Vinchevskaya-Khmelnitskaya, Aisha Agabalaeva, Natalia Ponomareva, Sergey Brezgin, Irina Goptar, Vladimir Chulanov, Alim Dymov, Andrey Vinarov, Dmitry Kostyushev, Anastasiya Kostyusheva","doi":"10.1134/S0006297924604441","DOIUrl":null,"url":null,"abstract":"<p>Bladder cancer (BCa) remains a significant clinical challenge because of high recurrence rates and variable response to immunotherapy and chemotherapy. Recent studies have highlighted the role of N6-methyladenosine (m<sup>6</sup>A) modification in RNA in the regulation of various cellular processes, including tumor progression and drug resistance. The review examines the impact of m<sup>6</sup>A methylation on BCa pathogenesis, with a particular special focus on the role of m<sup>6</sup>A pathway factors and m<sup>6</sup>A-modified RNAs in tumorigenesis, proliferation, invasion, and migration of cancer cells. The mechanisms of m<sup>6</sup>A-mediated chemotherapy resistance in BCa cells are discussed, including single nucleotide polymorphisms in m<sup>6</sup>A-associated patterns. Significant advances in the high-throughput analysis of m<sup>6</sup>A methylation have enabled development of novel m<sup>6</sup>A-based biomarkers for the risk assessment, early diagnostics, and prediction of relapse and treatment response in BCa. The review outlines the prospects of the m<sup>6</sup>A-based molecular diagnostics in BCa.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"90 ).","pages":"650 - 670"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow)","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0006297924604441","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Bladder cancer (BCa) remains a significant clinical challenge because of high recurrence rates and variable response to immunotherapy and chemotherapy. Recent studies have highlighted the role of N6-methyladenosine (m6A) modification in RNA in the regulation of various cellular processes, including tumor progression and drug resistance. The review examines the impact of m6A methylation on BCa pathogenesis, with a particular special focus on the role of m6A pathway factors and m6A-modified RNAs in tumorigenesis, proliferation, invasion, and migration of cancer cells. The mechanisms of m6A-mediated chemotherapy resistance in BCa cells are discussed, including single nucleotide polymorphisms in m6A-associated patterns. Significant advances in the high-throughput analysis of m6A methylation have enabled development of novel m6A-based biomarkers for the risk assessment, early diagnostics, and prediction of relapse and treatment response in BCa. The review outlines the prospects of the m6A-based molecular diagnostics in BCa.
期刊介绍：
Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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