Beneficial effects of aerobic exercises on multiple myeloma: Mechanisms and clinical observations.

IF 5.7 2区 医学 Q1 ONCOLOGY
Siyao He, Jingjing Wen, Zhongqing Zou, Linfeng Li, Xiaohui Zhao, Xiang Liu, Hongmei Luo, Jingcao Huang, Ziyue Mi, Yue Zhang, Qianwen Gao, Haonan Yang, Yu Feng, Xinyu Zhai, Fangfang Wang, Ting Niu, Li Zhang, Yuhuan Zheng
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引用次数: 0

Abstract

Studies on multiple myeloma (MM), the second most common hematologic malignancy, have shown inconclusive results regarding the role of exercise in treatment. This study evaluated the relationship between physical exercise and MM treatment outcomes. In the 5T-MM mouse model, tumor-bearing mice underwent treatment that included bortezomib and dexamethasone alongside 6 weeks of low- or moderate-intensity treadmill aerobic training. Tumor burden and survival data were recorded. Additionally, a retrospective analysis was conducted on 65 MM patients undergoing maintenance therapy at West China Hospital from 2013 to 2024. Patients were categorized based on their adherence to the World Health Organization (WHO) physical activity guidelines, and progression-free survival and progression-free survival in maintenance therapy were analyzed. In the mouse model, the combination of dual-drug therapy and exercise improved outcomes, extending survival by more than 10 days. Aerobic exercises reduced regulatory T cells and increased NK cells in the peripheral blood of mice. In the exercise group of mice, myokines IL-15 and irisin were up-regulated, implying both myokines could contribute to the regulation of anti-MM immunity. In the patient study, patients who met the WHO physical activity recommendations demonstrated significantly better progression-free survival (PFS) and progression-free survival in maintenance treatment (PFSm). Overall, appropriate aerobic exercises may benefit some MM patients, suggesting a potential for exercise as an adjunct in MM treatment.

有氧运动对多发性骨髓瘤的有益作用:机制和临床观察。
多发性骨髓瘤(MM)是第二大最常见的血液系统恶性肿瘤,研究表明,运动在治疗中的作用尚无定论。本研究评估体育锻炼与MM治疗结果之间的关系。在5T-MM小鼠模型中,荷瘤小鼠接受包括硼替佐米和地塞米松在内的治疗,同时进行6周的低或中强度跑步机有氧训练。记录肿瘤负荷和生存数据。并对2013 - 2024年在华西医院接受维持治疗的65例MM患者进行回顾性分析。根据患者对世界卫生组织(WHO)身体活动指南的依从性对患者进行分类,并分析维持治疗的无进展生存期和无进展生存期。在小鼠模型中,双药联合治疗和运动改善了结果,延长了10天以上的生存期。有氧运动减少了小鼠外周血中的调节性T细胞,增加了NK细胞。运动组小鼠的肌因子IL-15和鸢尾素上调,表明这两种肌因子都参与了抗mm免疫的调节。在患者研究中,符合世卫组织体力活动建议的患者表现出明显更好的无进展生存期(PFS)和维持治疗中的无进展生存期(PFSm)。总的来说,适当的有氧运动可能对一些MM患者有益,这表明运动可能作为MM治疗的辅助手段。
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来源期刊
CiteScore
13.40
自引率
3.10%
发文量
460
审稿时长
2 months
期刊介绍: The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories: -Cancer Epidemiology- Cancer Genetics and Epigenetics- Infectious Causes of Cancer- Innovative Tools and Methods- Molecular Cancer Biology- Tumor Immunology and Microenvironment- Tumor Markers and Signatures- Cancer Therapy and Prevention
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