Kailin Feng, Lei Sun, Zhidong Zhou, Jiayuan Alex Zhang, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang
{"title":"Macrophage-mimicking nanodiscs for treating systemic infection caused by methicillin-resistant Staphylococcus aureus","authors":"Kailin Feng, Lei Sun, Zhidong Zhou, Jiayuan Alex Zhang, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang","doi":"10.1126/sciadv.adw7511","DOIUrl":null,"url":null,"abstract":"<div >Antibiotic-resistant bacteria represent a critical public health challenge, underscoring the urgent need for innovative therapeutic strategies. Inspired by the unique properties of cell membrane–derived nanodiscs, particularly their ultrasmall size and intrinsic membrane functions, we develop macrophage membrane–derived nanodiscs (denoted “MФ-NDs”) as a nanomedicine for the treatment of systemic bacterial infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Our findings demonstrate that MФ-NDs interact directly with bacteria, disrupting their membranes, inducing leakage of intracellular contents, and ultimately causing bacterial death. Meanwhile, MФ-NDs reduce intracellular bacterial count. In a mouse model of systemic MRSA infection, treatment with MФ-NDs significantly improves survival rates in both therapeutic and preventative contexts. Moreover, MФ-NDs show a lower propensity to induce bacterial resistance compared to conventional small-molecule antibiotics. No acute toxicity is observed in mice treated with MФ-NDs. Overall, this study underscores the straightforward fabrication and promising potential of MФ-NDs for addressing antibiotic-resistant bacterial infections.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7511","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Advances","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/sciadv.adw7511","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Antibiotic-resistant bacteria represent a critical public health challenge, underscoring the urgent need for innovative therapeutic strategies. Inspired by the unique properties of cell membrane–derived nanodiscs, particularly their ultrasmall size and intrinsic membrane functions, we develop macrophage membrane–derived nanodiscs (denoted “MФ-NDs”) as a nanomedicine for the treatment of systemic bacterial infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Our findings demonstrate that MФ-NDs interact directly with bacteria, disrupting their membranes, inducing leakage of intracellular contents, and ultimately causing bacterial death. Meanwhile, MФ-NDs reduce intracellular bacterial count. In a mouse model of systemic MRSA infection, treatment with MФ-NDs significantly improves survival rates in both therapeutic and preventative contexts. Moreover, MФ-NDs show a lower propensity to induce bacterial resistance compared to conventional small-molecule antibiotics. No acute toxicity is observed in mice treated with MФ-NDs. Overall, this study underscores the straightforward fabrication and promising potential of MФ-NDs for addressing antibiotic-resistant bacterial infections.
期刊介绍:
Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.