Early and Late Buzzards: Comparing Different Approaches for Quantile-Based Multiple Testing in Heavy-Tailed Wildlife Research Data

IF 1.8 3区 生物学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Marléne Baumeister, Merle Munko, Kai-Philipp Gladow, Marc Ditzhaus, Nayden Chakarov, Markus Pauly
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引用次数: 0

Abstract

In medical, ecological, and psychological research, there is a need for methods to handle multiple testing, for example, to consider group comparisons with more than two groups. Typical approaches that deal with multiple testing are mean- or variance-based which can be less effective in the context of heavy-tailed and skewed data. Here, the median is the preferred measure of location and the interquartile range (IQR) is an adequate alternative to the variance. Therefore, it may be fruitful to formulate research questions of interest in terms of the median or the IQR. For this reason, we compare different inference approaches for two-sided and noninferiority hypotheses formulated in terms of medians or IQRs in an extensive simulation study. We consider multiple contrast testing procedures combined with a bootstrap method as well as testing procedures with Bonferroni correction. As an example of a multiple testing problem based on heavy-tailed data, we analyze an ecological trait variation in early and late breeding in a medium-sized bird of prey.

Abstract Image

早秃鹰和晚秃鹰:比较重尾野生动物研究数据中基于分位数的多重测试的不同方法
在医学、生态学和心理学研究中,需要有处理多重测试的方法,例如,考虑两组以上的群体比较。处理多重检验的典型方法是基于均值或方差的,这在重尾和偏斜数据的背景下可能不太有效。在这里,中位数是首选的位置度量,四分位数范围(IQR)是方差的适当替代。因此,根据中位数或IQR来制定感兴趣的研究问题可能是富有成效的。出于这个原因,我们比较了在广泛的模拟研究中根据中位数或iqr制定的双边和非劣效性假设的不同推断方法。我们考虑多种对比测试程序与自举方法相结合,以及测试程序与邦费罗尼校正。以中型猛禽为例,分析了其在繁殖早期和后期的生态性状变异。
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来源期刊
Biometrical Journal
Biometrical Journal 生物-数学与计算生物学
CiteScore
3.20
自引率
5.90%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Biometrical Journal publishes papers on statistical methods and their applications in life sciences including medicine, environmental sciences and agriculture. Methodological developments should be motivated by an interesting and relevant problem from these areas. Ideally the manuscript should include a description of the problem and a section detailing the application of the new methodology to the problem. Case studies, review articles and letters to the editors are also welcome. Papers containing only extensive mathematical theory are not suitable for publication in Biometrical Journal.
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