Strontium-enriched phosphate coating on fused filament fabrication 3D printed alumina scaffolds

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-07-03 DOI:10.1016/j.matlet.2025.139033

E.Y. Nagata , F.C. Nunes , L. Santana , Z.C. Silveira , J.A. Ferreira , C.E. Ambrósio , E.M.J.A. Pallone

引用次数: 0

Abstract

This study explored fused filament fabrication (FFF) of alumina (Al₂O₃) scaffolds using commercial filament with a polyolefin-based binder for bone substitute applications. Scaffolds, fabricated via a low-cost 3D printer, underwent acetone and thermal debinding, followed by sintering. Micro-CT of uncoated scaffolds revealed high porosity, including interconnected macropores and microporosity, suitable for osseointegration, osteoblast growth, and vascularization. Uncoated scaffolds exhibited high compressive strength, comparable to trabecular bone. Biomimetic coating with calcium and strontium phosphates via simulated body fluid immersion, characterized by XRD, FTIR, and SEM, is expected to enhance bioactivity, promoting cell-material interactions. The scaffolds’ shape fidelity and scalable fabrication suggest strong potential for tissue engineering applications.

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富锶磷酸盐熔丝涂层制备3D打印氧化铝支架

本研究探索了氧化铝（Al2O3）支架的熔融长丝制造（FFF），使用商业长丝和聚烯烃基粘合剂用于骨替代品的应用。支架通过低成本3D打印机制造，经过丙酮和热脱脂，然后烧结。未包被支架的Micro-CT显示高孔隙度，包括相互连接的大孔和微孔，适合骨整合、成骨细胞生长和血管形成。未包覆支架表现出高抗压强度，与小梁骨相当。通过x射线衍射（XRD）、红外光谱（FTIR）和扫描电镜（SEM）对模拟体液浸泡的磷酸钙和锶仿生涂层进行表征，有望增强生物活性，促进细胞-物质相互作用。支架的形状保真度和可扩展的制造表明了组织工程应用的强大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive