Effects of cyanobacterial oligopeptides: Anabaenopeptin-B, aeruginosin-98B and their mixture on oxidative stress biomarkers, HSP70 production and tyrosine phosphatase activity in three aquatic invertebrate species: Brachionus calyciflorus, Thamnocephalus platyurus, and Chironomus aprilinus

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-07-05 DOI:10.1016/j.etap.2025.104755

Adam Bownik, Barbara Pawlik-Skowrońska

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Abstract

The aim of the study was to determine the effects of anabaenopeptin-B (ANA-B), aeruginosin 98 (AER-B) and their binary mixture (ANA-B+AER-B) on biomarkers of oxidative stress (glutathione (GSH), superoxide dismutase SOD, total nitric oxide (NO), catalase (CAT), lipid peroxidation (LPO), hemoglobin (Hb) level, heat shock protein HSP70 and tyrosine phosphatase activity in three aquatic invertebrates Brachionus calyciflorus, Thamnocephalus platyurus and Chironomus aprilinus. The results revealed alterations of the tested parameters in response to the tested cyanobacterial metabolites with various interactions in the mixtures. The study suggests that During natural exposure to cyanobacterial metabolites and their mixtures different responses to oligopeptides in the group of may occur in aquatic invertebrates. Total effects of mixtures may depend on the structure, type of components and sensitivity of the exposed invertebrate species.

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蓝藻寡肽Anabaenopeptin-B、aeruginosin-98B及其混合物对萼花臂尾虫、鸭嘴兽和aprilinus三种水生无脊椎动物氧化应激生物标志物、HSP70产量和酪氨酸磷酸酶活性的影响

本研究旨在研究鸭绿肽- b （ANA-B）、绿脓毒苷98 （AER-B）及其二组分（ANA-B+AER-B）对花苞臂尾虫、鸭嘴兽和aprilinus 3种水生无脊椎动物氧化应激生物标志物(谷胱甘肽（GSH）、超氧化物歧化酶SOD、总一氧化氮（NO）、过氧化氢酶（CAT）、脂质过氧化（LPO）、血红蛋白（Hb）水平、热休克蛋白HSP70和酪氨酸磷酸酶活性的影响。结果揭示了测试参数的变化，以响应测试的蓝藻代谢物与混合物中的各种相互作用。该研究表明，在自然暴露于蓝藻代谢物及其混合物期间，水生无脊椎动物可能会对组中的寡肽产生不同的反应。混合物的总影响可能取决于暴露的无脊椎动物物种的结构、成分类型和敏感性。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.